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Literature summary extracted from

  • Nassi, P.; Nediani, C.; Fiorillo, C.; Marchetti, E.; Liguri, G.; Ramponi,G.
    Modifications induced by acylphosphatase in the functional properties of heart sarcolemma Na+,K+ pump (1994), FEBS Lett., 337, 109-113.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.7 0.000069
-
 Na+/K+-ATPase phosphoenzyme intermediate cardiac muscle, phoshoenzyme intermediate of heart sarcolemma Na+,K+-ATPase Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.7 cytoplasm
-
 Bos taurus 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.7 additional information Bos taurus acylphosphatase increases the rate of Na+,K+-dependent ATP hydrolysis, acylphosphatase significantly stimulates the rate of ATP driven Na+ transport into sarcolemma vesicles: accelerrated hydrolysis of the phosphoenzyme may result in an enhanced activity of heart sarcolemma Na+,K+ pump, suggesting a potential role of acylphosphatase in the control of this active transport system ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.7 Bos taurus
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 bovine
-
3.6.1.7 Bos taurus
-
 two isoenzymatic forms: one prevalent in skeletal and cardiac muscle, the other in red blood cells
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.7 heart, cardiac muscle Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.7 heart cardiac muscle Bos taurus
-
3.6.1.7 muscle cardiac muscle Bos taurus
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.6.1.7 3650
-
 heart, cardiac muscle Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.7 (Ca2+-Mg2+)-ATPase phosphorylated intermediate + H2O acylphosphorylated intermediates of Ca2+-ATPase from skeletal muscle sarcoplasmic reticulum and heart sarcolemma Bos taurus ?
-
 ?
3.6.1.7 1,3-diphosphoglycerate + H2O
-
 Bos taurus 3-phosphoglycerate + phosphate
-
 ?
3.6.1.7 acylphosphate + H2O specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates Bos taurus carboxylate + phosphate
-
 ?
3.6.1.7 benzoyl phosphate + H2O
-
 Bos taurus benzoate + phosphate
-
 ?
3.6.1.7 carbamoyl phosphate + H2O
-
 Bos taurus carbamate + phosphate
-
 ?
3.6.1.7 additional information acylphosphatase increases the rate of Na+,K+-dependent ATP hydrolysis, acylphosphatase significantly stimulates the rate of ATP driven Na+ transport into sarcolemma vesicles: accelerrated hydrolysis of the phosphoenzyme may result in an enhanced activity of heart sarcolemma Na+,K+ pump, suggesting a potential role of acylphosphatase in the control of this active transport system Bos taurus ?
-
 ?
3.6.1.7 Na+/K+-ATPase phosphoenzyme intermediate + H2O sarcolemma Na+,K+-ATPase phosphorylated intermediate Bos taurus ?
-
 ?
3.6.1.7 Na+/K+-ATPase phosphoenzyme intermediate + H2O acylphosphatase significantly enhances the rate of strophantidine-sensitive ATP hydrolysis, it uncouples erythrocyte membrane N+,K+ pump Bos taurus ?
-
 ?
3.6.1.7 Na+/K+-ATPase phosphoenzyme intermediate + H2O acylphosphatase hydrolyzes phosphoenzyme intermediate of heart sarcolemma Na+,K+-ATPase Bos taurus ?
-
 ?
3.6.1.7 Na+/K+-ATPase phosphoenzyme intermediate + H2O acylphosphatase increases the rate of Na+,K+-dependent ATP hydrolysis, acylphosphatase significantly stimulates the rate of ATP driven Na+ transport into sarcolemma vesicles: accelerated hydrolysis of the phosphoenzyme may result in an enhanced activity of heart sarcolemma Na+,K+ pump, suggesting a potential role of acylphosphatase in the control of this active transport system Bos taurus ?
-
 ?
3.6.1.7 Na+/K+-ATPase phosphoenzyme intermediate + H2O acylphosphorylated phosphoenzyme intermediate, enzyme has a high affinity for this substrate Bos taurus ?
-
 ?
3.6.1.7 succinoyl phosphate + H2O
-
 Bos taurus succinate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.7 More two isoenzymatic forms: one prevalent in skeletal and cardiac muscle named muscle type, the other in red blood cells named erythrocyte or common type, even if both isoforms are expressed in all tissues Bos taurus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.6.1.7 100
-
 2 h: heat inactivation Bos taurus