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Literature summary extracted from

  • Johnson, W.J.; Gadd, R.E.A.
    Inhibition of nicotinamide deaminase from Micrococcus lysodeikticus by analogues of nicotinamide (1974), Int. J. Biochem., 5, 633-641.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.19 3-(3-pyridyl)-1-propanol moderate Micrococcus luteus
3.5.1.19 3-acetylpyridine moderate Micrococcus luteus
3.5.1.19 3-aminomethylpyridine potent Micrococcus luteus
3.5.1.19 3-chloropyridine moderate Micrococcus luteus
3.5.1.19 3-Cyanopyridine potent Micrococcus luteus
3.5.1.19 3-Pyridineacetonitrile moderate Micrococcus luteus
3.5.1.19 3-pyridinealdoxime potent Micrococcus luteus
3.5.1.19 3-Pyridinecarboxaldehyde potent Micrococcus luteus
3.5.1.19 3-Pyridylcarbinol potent Micrococcus luteus
3.5.1.19 4-aminonicotinamide potent Micrococcus luteus
3.5.1.19 5-Methylnicotinamide moderate Micrococcus luteus
3.5.1.19 isoniazid moderate Micrococcus luteus
3.5.1.19 additional information pyridine nitrogen and the carbonyl carbon of nicotinamide are involved in substrate-enzyme binding, and the enzyme exhibits steric hindrance in binding nicotinamide analogues with substituents at the 1-position, 5-position, and 6-positions of the pyridine ring Micrococcus luteus
3.5.1.19 nicotinal hydroxamic acid moderate Micrococcus luteus
3.5.1.19 nicotinic acid hydrazide potent Micrococcus luteus
3.5.1.19 nipecotamide moderate Micrococcus luteus
3.5.1.19 o-bromobenzamide moderate Micrococcus luteus
3.5.1.19 Pyrazinamide moderate Micrococcus luteus
3.5.1.19 Thionicotinamide moderate Micrococcus luteus

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.19 Micrococcus luteus
-
 i.e. Micrococcus lysodeiktikus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.19 nicotinamide + H2O
-
 Micrococcus luteus nicotinate + NH3
-
 ?