Literature summary extracted from

Jacques, S.L.; Nieman, C.; Bareich, D.; Broadhead, G.; Kinach, R.; Honek, J.F.; Wright, G.D.
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity (2001), Biochim. Biophys. Acta, 1544, 28-41.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.1.1.3	overexpression in Escherichia coli	Saccharomyces cerevisiae

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.1.1.3	H309A	decrease of catalytic activity and elimination of substrate inhibition	Saccharomyces cerevisiae

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.3	Saccharomyces cerevisiae	P31116	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.1.1.3	overexpressed in Escherichia coli	Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
1.1.1.3	23.7	-	-	Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.3	L-aspartate 4-semialdehyde + NAD(P)H	-	Saccharomyces cerevisiae	L-homoserine + NAD(P)+	-	?
1.1.1.3	L-homoserine + NAD(P)+	-	Saccharomyces cerevisiae	L-aspartate 4-semialdehyde + NAD(P)H	-	r

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Release 2023.1 (January 2023)