BRENDA - Enzyme Database show

Homoserine dehydrogenase from Saccharomyces cerevisiae: kinetic mechanism and stereochemistry of hydride transfer

Jacques, S.L.; Ejim, L.J.; Wright, G.D.; Biochim. Biophys. Acta 1544, 42-54 (2001)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.3
(S)-2-amino-4-oxo-5-hydroxypentanoic acid
RI-331
Saccharomyces cerevisiae
1.1.1.3
H-(1,2,4-triazol-3-yl)-DL-alanine
-
Saccharomyces cerevisiae
1.1.1.3
L-threonine
weakly inhibits reverse but not forward reaction
Saccharomyces cerevisiae
1.1.1.3
methionine
weakly inhibits reverse but not forward reaction
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.3
L-aspartate 4-semialdehyde + NAD(P)H
Saccharomyces cerevisiae
kinetic mechanism
L-homoserine + NAD(P)+
-
-
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.3
Saccharomyces cerevisiae
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.3
L-aspartate 4-semialdehyde + NAD(P)H
-
246401
Saccharomyces cerevisiae
L-homoserine + NAD(P)+
-
246401
Saccharomyces cerevisiae
r
1.1.1.3
L-aspartate 4-semialdehyde + NAD(P)H
kinetic mechanism
246401
Saccharomyces cerevisiae
L-homoserine + NAD(P)+
-
-
-
r
1.1.1.3
L-homoserine + NAD(P)+
-
246401
Saccharomyces cerevisiae
L-aspartate 4-semialdehyde + NAD(P)H
-
246401
Saccharomyces cerevisiae
r
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.3
(S)-2-amino-4-oxo-5-hydroxypentanoic acid
RI-331
Saccharomyces cerevisiae
1.1.1.3
H-(1,2,4-triazol-3-yl)-DL-alanine
-
Saccharomyces cerevisiae
1.1.1.3
L-threonine
weakly inhibits reverse but not forward reaction
Saccharomyces cerevisiae
1.1.1.3
methionine
weakly inhibits reverse but not forward reaction
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.3
L-aspartate 4-semialdehyde + NAD(P)H
Saccharomyces cerevisiae
kinetic mechanism
L-homoserine + NAD(P)+
-
-
r
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.3
L-aspartate 4-semialdehyde + NAD(P)H
-
246401
Saccharomyces cerevisiae
L-homoserine + NAD(P)+
-
246401
Saccharomyces cerevisiae
r
1.1.1.3
L-aspartate 4-semialdehyde + NAD(P)H
kinetic mechanism
246401
Saccharomyces cerevisiae
L-homoserine + NAD(P)+
-
-
-
r
1.1.1.3
L-homoserine + NAD(P)+
-
246401
Saccharomyces cerevisiae
L-aspartate 4-semialdehyde + NAD(P)H
-
246401
Saccharomyces cerevisiae
r