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Literature summary extracted from

  • Jacques, S.L.; Ejim, L.J.; Wright, G.D.
    Homoserine dehydrogenase from Saccharomyces cerevisiae: kinetic mechanism and stereochemistry of hydride transfer (2001), Biochim. Biophys. Acta, 1544, 42-54.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.3 (S)-2-amino-4-oxo-5-hydroxypentanoic acid RI-331 Saccharomyces cerevisiae
1.1.1.3 H-(1,2,4-triazol-3-yl)-DL-alanine
-
 Saccharomyces cerevisiae
1.1.1.3 L-threonine weakly inhibits reverse but not forward reaction Saccharomyces cerevisiae
1.1.1.3 methionine weakly inhibits reverse but not forward reaction Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H Saccharomyces cerevisiae kinetic mechanism L-homoserine + NAD(P)+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.3 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H
-
 Saccharomyces cerevisiae L-homoserine + NAD(P)+
-
 r
1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H kinetic mechanism Saccharomyces cerevisiae L-homoserine + NAD(P)+
-
 r
1.1.1.3 L-homoserine + NAD(P)+
-
 Saccharomyces cerevisiae L-aspartate 4-semialdehyde + NAD(P)H
-
 r