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Literature summary extracted from

  • Cavari, B.Z.; Grossowicz, N.
    Properties of homoserine dehydrogenase in a thermophilic bacterium (1973), Biochim. Biophys. Acta, 302, 183-190.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.3 D-threonine slight Thermophilic bacterium
1.1.1.3 DL-allo-threonine
-
 Thermophilic bacterium
1.1.1.3 L-cysteine slight Thermophilic bacterium
1.1.1.3 L-threonine
-
 Thermophilic bacterium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.3 0.17 0.18 NADP+
-
 Thermophilic bacterium

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.3 K+ required Thermophilic bacterium
1.1.1.3 Li+ can partially replace K+ Thermophilic bacterium
1.1.1.3 Na+ can partially replace K+ Thermophilic bacterium
1.1.1.3 NH4+ can partially replace K+ Thermophilic bacterium
1.1.1.3 Rb+ can partially replace K+ Thermophilic bacterium

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.3 Thermophilic bacterium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.3
-
 Thermophilic bacterium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H
-
 Thermophilic bacterium L-homoserine + NAD(P)+
-
 r
1.1.1.3 L-homoserine + NAD(P)+
-
 Thermophilic bacterium L-aspartate 4-semialdehyde + NAD(P)H
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.3 70
-
-
 Thermophilic bacterium

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.1.1.3 20 70 no activity at 80°C Thermophilic bacterium

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.3 9.8
-
-
 Thermophilic bacterium

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.3 8 10
-
 Thermophilic bacterium

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.3 NAD+ low activity Thermophilic bacterium
1.1.1.3 NADP+ preferred Thermophilic bacterium