BRENDA - Enzyme Database show

Properties of homoserine dehydrogenase in a thermophilic bacterium

Cavari, B.Z.; Grossowicz, N.; Biochim. Biophys. Acta 302, 183-190 (1973)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.3
D-threonine
slight
Thermophilic bacterium
1.1.1.3
DL-allo-threonine
-
Thermophilic bacterium
1.1.1.3
L-cysteine
slight
Thermophilic bacterium
1.1.1.3
L-threonine
-
Thermophilic bacterium
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.1.1.3
0.17
0.18
NADP+
-
Thermophilic bacterium
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
1.1.1.3
K+
required
Thermophilic bacterium
1.1.1.3
Li+
can partially replace K+
Thermophilic bacterium
1.1.1.3
Na+
can partially replace K+
Thermophilic bacterium
1.1.1.3
NH4+
can partially replace K+
Thermophilic bacterium
1.1.1.3
Rb+
can partially replace K+
Thermophilic bacterium
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.3
Thermophilic bacterium
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
1.1.1.3
-
Thermophilic bacterium
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.3
L-aspartate 4-semialdehyde + NAD(P)H
-
246392
Thermophilic bacterium
L-homoserine + NAD(P)+
-
246392
Thermophilic bacterium
r
1.1.1.3
L-homoserine + NAD(P)+
-
246392
Thermophilic bacterium
L-aspartate 4-semialdehyde + NAD(P)H
-
246392
Thermophilic bacterium
r
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
1.1.1.3
70
-
-
Thermophilic bacterium
Temperature Range [°C]
EC Number
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
1.1.1.3
20
70
no activity at 80°C
Thermophilic bacterium
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.1.1.3
9.8
-
-
Thermophilic bacterium
pH Range
EC Number
pH Minimum
pH Maximum
Commentary
Organism
1.1.1.3
8
10
-
Thermophilic bacterium
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.3
NAD+
low activity
Thermophilic bacterium
1.1.1.3
NADP+
preferred
Thermophilic bacterium
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.3
NAD+
low activity
Thermophilic bacterium
1.1.1.3
NADP+
preferred
Thermophilic bacterium
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.3
D-threonine
slight
Thermophilic bacterium
1.1.1.3
DL-allo-threonine
-
Thermophilic bacterium
1.1.1.3
L-cysteine
slight
Thermophilic bacterium
1.1.1.3
L-threonine
-
Thermophilic bacterium
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.1.1.3
0.17
0.18
NADP+
-
Thermophilic bacterium
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
1.1.1.3
K+
required
Thermophilic bacterium
1.1.1.3
Li+
can partially replace K+
Thermophilic bacterium
1.1.1.3
Na+
can partially replace K+
Thermophilic bacterium
1.1.1.3
NH4+
can partially replace K+
Thermophilic bacterium
1.1.1.3
Rb+
can partially replace K+
Thermophilic bacterium
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.1.1.3
-
Thermophilic bacterium
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.3
L-aspartate 4-semialdehyde + NAD(P)H
-
246392
Thermophilic bacterium
L-homoserine + NAD(P)+
-
246392
Thermophilic bacterium
r
1.1.1.3
L-homoserine + NAD(P)+
-
246392
Thermophilic bacterium
L-aspartate 4-semialdehyde + NAD(P)H
-
246392
Thermophilic bacterium
r
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
1.1.1.3
70
-
-
Thermophilic bacterium
Temperature Range [°C] (protein specific)
EC Number
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
1.1.1.3
20
70
no activity at 80°C
Thermophilic bacterium
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.1.1.3
9.8
-
-
Thermophilic bacterium
pH Range (protein specific)
EC Number
pH Minimum
pH Maximum
Commentary
Organism
1.1.1.3
8
10
-
Thermophilic bacterium