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Literature summary extracted from

  • Grego, S.; Tricoli, D.; Di Marco, G.
    Comparison of homoserine dehydrogenase from different plant sources (1980), Phytochemistry, 19, 1619-1623.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.3 L-threonine degree of inhibition depends on age of plant; sensitive and insensitive isozymes Pisum sativum
1.1.1.3 L-threonine degree of inhibition depends on age of plant; sensitive and insensitive isozymes Ricinus communis
1.1.1.3 L-threonine degree of inhibition depends on age of plant; sensitive and insensitive isozymes Triticum aestivum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.3 0.031
-
 NADPH threonine sensitive isozyme Triticum aestivum
1.1.1.3 0.032 0.036 NADPH threonine resistant isozyme Triticum aestivum
1.1.1.3 0.043
-
 NADPH threonine sensitive isozyme Triticum aestivum
1.1.1.3 0.13 0.15 L-aspartate 4-semialdehyde threonine resistant isozyme Triticum aestivum
1.1.1.3 0.24 0.25 L-aspartate 4-semialdehyde threonine sensitive isozyme Triticum aestivum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.3 Cs+ activation of threonine sensitive enzyme Triticum aestivum
1.1.1.3 Cs+ activation of threonine sensitive enzyme Pisum sativum
1.1.1.3 Cs+ activation of threonine sensitive enzyme Ricinus communis
1.1.1.3 K+ activation of threonine sensitive isozyme Triticum aestivum
1.1.1.3 K+ activation of threonine sensitive isozyme Pisum sativum
1.1.1.3 K+ activation of threonine sensitive isozyme Ricinus communis
1.1.1.3 Li+ activation of threonine sensitive isozyme Triticum aestivum
1.1.1.3 Li+ activation of threonine sensitive isozyme Pisum sativum
1.1.1.3 Li+ activation of threonine sensitive isozyme Ricinus communis
1.1.1.3 Na+ activation of threonine sensitive form Triticum aestivum
1.1.1.3 Na+ activation of threonine sensitive form Pisum sativum
1.1.1.3 Na+ activation of threonine sensitive form Ricinus communis
1.1.1.3 NH4+ activation of threonine sensitive isozyme Triticum aestivum
1.1.1.3 NH4+ activation of threonine sensitive isozyme Pisum sativum
1.1.1.3 NH4+ activation of threonine sensitive isozyme Ricinus communis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.3 75000
-
 gel filtration, threonine insensitive isozyme Triticum aestivum
1.1.1.3 75000
-
 gel filtration, threonine insensitive isozyme Pisum sativum
1.1.1.3 80000
-
 disc gel electrophoresis, threonine insensitive isozyme Ricinus communis
1.1.1.3 280000
-
 disc gel electrophoresis, threonine sensitive isozyme Ricinus communis
1.1.1.3 290000
-
 gel filtration, threonine sensitive isozyme Triticum aestivum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H Triticum aestivum
-
 L-homoserine + NAD(P)+
-
 r
1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H Pisum sativum
-
 L-homoserine + NAD(P)+
-
 r
1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H Ricinus communis
-
 L-homoserine + NAD(P)+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.3 Pisum sativum
-
 pea
-
1.1.1.3 Ricinus communis
-
 castor bean
-
1.1.1.3 Triticum aestivum
-
 wheat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.3
-
 Triticum aestivum
1.1.1.3
-
 Pisum sativum
1.1.1.3
-
 Ricinus communis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.3 seedling
-
 Triticum aestivum
-
1.1.1.3 seedling
-
 Pisum sativum
-
1.1.1.3 seedling
-
 Ricinus communis
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.3 0.17
-
-
 Triticum aestivum
1.1.1.3 2.8
-
-
 Pisum sativum
1.1.1.3 6.8
-
-
 Ricinus communis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H
-
 Triticum aestivum L-homoserine + NAD(P)+
-
 r
1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H
-
 Pisum sativum L-homoserine + NAD(P)+
-
 r
1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H
-
 Ricinus communis L-homoserine + NAD(P)+
-
 r
1.1.1.3 L-homoserine + NAD(P)+
-
 Triticum aestivum L-aspartate 4-semialdehyde + NAD(P)H
-
 r
1.1.1.3 L-homoserine + NAD(P)+
-
 Pisum sativum L-aspartate 4-semialdehyde + NAD(P)H
-
 r
1.1.1.3 L-homoserine + NAD(P)+
-
 Ricinus communis L-aspartate 4-semialdehyde + NAD(P)H
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.3 NADH threonine sensitive isozyme can use NADPH or NADH, threonine insensitive isozyme can use NADPH only Triticum aestivum
1.1.1.3 NADH threonine sensitive isozyme can use NADPH or NADH, threonine insensitive isozyme can use NADPH only Pisum sativum
1.1.1.3 NADH threonine sensitive isozyme can use NADPH or NADH, threonine insensitive isozyme can use NADPH only Ricinus communis
1.1.1.3 NADPH threonine sensitive isozyme can use NADPH or NADH, threonine insensitive isozyme can use NADPH only Triticum aestivum
1.1.1.3 NADPH threonine sensitive isozyme can use NADPH or NADH, threonine insensitive isozyme can use NADPH only Pisum sativum
1.1.1.3 NADPH threonine sensitive isozyme can use NADPH or NADH, threonine insensitive isozyme can use NADPH only Ricinus communis