BRENDA - Enzyme Database show

Kinetic and regulatory mechanisms for (Escherichia coli) homoserine dehydrogenase-I

Wedler, F.C.; Ley, B.W.; J. Biol. Chem. 268, 4880-4888 (1993)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.3
L-threonine
-
Escherichia coli
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.1.1.3
0.013
-
L-homoserine
-
Escherichia coli
1.1.1.3
0.073
-
NADP+
-
Escherichia coli
1.1.1.3
0.09
-
NADPH
-
Escherichia coli
1.1.1.3
0.17
-
L-aspartate 4-semialdehyde
-
Escherichia coli
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.3
L-aspartate 4-semialdehyde + NAD(P)H
Escherichia coli
kinetic mechanism
L-homoserine + NAD(P)+
-
-
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.3
Escherichia coli
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.3
L-aspartate 4-semialdehyde + NAD(P)H
-
246387
Escherichia coli
L-homoserine + NAD(P)+
-
246387
Escherichia coli
r
1.1.1.3
L-aspartate 4-semialdehyde + NAD(P)H
kinetic mechanism
246387
Escherichia coli
L-homoserine + NAD(P)+
-
-
-
r
1.1.1.3
L-homoserine + NAD(P)+
-
246387
Escherichia coli
L-aspartate 4-semialdehyde + NAD(P)H
-
246387
Escherichia coli
r
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.3
NADP+
-
Escherichia coli
1.1.1.3
NADPH
-
Escherichia coli
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.3
NADP+
-
Escherichia coli
1.1.1.3
NADPH
-
Escherichia coli
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.3
L-threonine
-
Escherichia coli
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.1.1.3
0.013
-
L-homoserine
-
Escherichia coli
1.1.1.3
0.073
-
NADP+
-
Escherichia coli
1.1.1.3
0.09
-
NADPH
-
Escherichia coli
1.1.1.3
0.17
-
L-aspartate 4-semialdehyde
-
Escherichia coli
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.3
L-aspartate 4-semialdehyde + NAD(P)H
Escherichia coli
kinetic mechanism
L-homoserine + NAD(P)+
-
-
r
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.3
L-aspartate 4-semialdehyde + NAD(P)H
-
246387
Escherichia coli
L-homoserine + NAD(P)+
-
246387
Escherichia coli
r
1.1.1.3
L-aspartate 4-semialdehyde + NAD(P)H
kinetic mechanism
246387
Escherichia coli
L-homoserine + NAD(P)+
-
-
-
r
1.1.1.3
L-homoserine + NAD(P)+
-
246387
Escherichia coli
L-aspartate 4-semialdehyde + NAD(P)H
-
246387
Escherichia coli
r