EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.2.22 | expressed in COS-1 cells | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.2.22 | endoplasmic reticulum | in contrast to the wild type enzyme, the mutant polypeptides are retained in the endoplasmic reticulum, most probably due to the misfolding of the mutant polypeptide | Homo sapiens | 5783 | - |
3.1.2.22 | lysosome | - |
Homo sapiens | 5764 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.2.22 | additional information | Homo sapiens | defect in the palmitoyl-(protein) hydrolase gene causes a neurodegenerative disorder. Depalmitoylation of the still uncharacterized substrate(s) of the enzyme is critical for postnatal development or maintainance of cortical neurons | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.2.22 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.1.2.22 | glycoprotein | heterogenous glycosylation is the major cause of multiple bands observed in SDS-PAGE | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.2.22 | additional information | defect in the palmitoyl-(protein) hydrolase gene causes a neurodegenerative disorder. Depalmitoylation of the still uncharacterized substrate(s) of the enzyme is critical for postnatal development or maintainance of cortical neurons | Homo sapiens | ? | - |
? | |
3.1.2.22 | palmitoyl-[protein] + H2O | various S-acylated proteins | Homo sapiens | palmitate + protein | - |
? |