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Literature summary extracted from

  • Smeland, T.E.; Li, J.; Cuebas, D.; Schulz, H.
    The mechanism and function of 3-hydroxyacyl-CoA epimerase in rat liver and Escherichia coli (1992), Prog. Clin. Biol. Res., 375, 85-93.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.2.3 additional information Rattus norvegicus
-
 ?
-
 ?
5.1.2.3 additional information Gram-negative bacteria
-
 ?
-
 ?
5.1.2.3 additional information Mammalia 3-hydroxyacyl-CoA epimerase activity as a part of a system capable of degrading products formed as a result of Gram-negative bacterial infections. In addition the enzyme may play a role in the metabolism of leukotrienes, specifically 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid, i.e. the 5-lipoxygenase oxidation product of arachidonic acid ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.1.2.3 Candida tropicalis
-
-
-
5.1.2.3 Cucumis sativus
-
 cucumber
-
5.1.2.3 Escherichia coli
-
-
-
5.1.2.3 Gram-negative bacteria
-
-
-
5.1.2.3 Mammalia
-
-
-
5.1.2.3 Neurospora crassa
-
-
-
5.1.2.3 Pseudomonas fragi
-
-
-
5.1.2.3 Rattus norvegicus
-
-
-
5.1.2.3 Yarrowia lipolytica
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
5.1.2.3 (S)-3-Hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA epimerization occurs solely by a dehydration/hydration mechanism Escherichia coli
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.1.2.3 liver
-
 Rattus norvegicus
-
5.1.2.3 seed
-
 Cucumis sativus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.2.3 additional information
-
 Rattus norvegicus ?
-
 ?
5.1.2.3 additional information
-
 Gram-negative bacteria ?
-
 ?
5.1.2.3 additional information 3-hydroxyacyl-CoA epimerase activity as a part of a system capable of degrading products formed as a result of Gram-negative bacterial infections. In addition the enzyme may play a role in the metabolism of leukotrienes, specifically 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid, i.e. the 5-lipoxygenase oxidation product of arachidonic acid Mammalia ?
-
 ?