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Literature summary extracted from

  • Kim, S.S.; Datta, P.
    Chemical characterization of biodegradative threonine dehydratases from two enteric bacteria (1982), Biochim. Biophys. Acta, 706, 27-35.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.1.19 pyruvate uncompetitive inhibition and substrate inhibition with respect to L-Thr, noncompetitive inhibition with respect to AMP Escherichia coli
4.3.1.19 pyruvate noncompetitive inhibition with respect to L-Thr, mixed type inhibition with respect to AMP Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.1.19 3
-
 L-Thr with AMP Salmonella enterica subsp. enterica serovar Typhimurium
4.3.1.19 8
-
 L-Thr with AMP Salmonella enterica subsp. enterica serovar Typhimurium
4.3.1.19 70
-
 L-Thr without AMP Escherichia coli
4.3.1.19 125
-
 L-Thr without AMP Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.3.1.19 36000
-
 x * 36000, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
4.3.1.19 38000
-
 x * 38000, SDS-PAGE Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.19 Escherichia coli
-
-
-
4.3.1.19 Escherichia coli
-
 biodegradative threonine dehydratase
-
4.3.1.19 Escherichia coli
-
 ATCC 14948
-
4.3.1.19 Escherichia coli K 12
-
-
-
4.3.1.19 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
4.3.1.19 Salmonella enterica subsp. enterica serovar Typhimurium
-
 biodegradative threonine dehydratase
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.19 L-threonine
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-oxobutanoate + NH3
-
 ?
4.3.1.19 L-threonine
-
 Escherichia coli 2-oxobutanoate + NH3
-
 ?
4.3.1.19 L-threonine
-
 Escherichia coli K 12 2-oxobutanoate + NH3
-
 ?

Subunits

EC Number Subunits Comment Organism
4.3.1.19 tetramer x * 38000, SDS-PAGE Escherichia coli
4.3.1.19 tetramer x * 36000, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

EC Number Cofactor Comment Organism Structure
4.3.1.19 ADP stimulation Salmonella enterica subsp. enterica serovar Typhimurium
4.3.1.19 ADP no stimulation by ADP Escherichia coli
4.3.1.19 pyridoxal 5'-phosphate cofactor Salmonella enterica subsp. enterica serovar Typhimurium
4.3.1.19 pyridoxal 5'-phosphate cofactor Escherichia coli
4.3.1.19 pyridoxal 5'-phosphate contains 2 mol of pyridoxal 5'-phosphate per mol of enzyme Salmonella enterica subsp. enterica serovar Typhimurium
4.3.1.19 pyridoxal 5'-phosphate contains 2 mol of pyridoxal 5'-phosphate per mol of enzyme Escherichia coli