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Literature summary extracted from

  • Laakmann-Ditges, G.; Klemme, J.H.
    Amino acid metabolism in the thermophilic phototroph, Chloroflexus aurantiacus: properties and metabolic role of two L-threonine (L-serine) dehydratases (1988), Arch. Microbiol., 149, 249-254.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.1.19 D-Thr
-
 Chloroflexus aurantiacus
4.3.1.19 Ile 2 enzyme forms: an isoleucine-sensitive enzyme form and and isoleucine-insensitive form, pH-dependence of inhibition Chloroflexus aurantiacus
4.3.1.19 NaBH4
-
 Chloroflexus aurantiacus
4.3.1.19 Ser D-Ser Chloroflexus aurantiacus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.1.19 1.3
-
 L-Thr Ile-sensitive enzyme Chloroflexus aurantiacus
4.3.1.19 10
-
 L-Ser Ile-insensitive enzyme Chloroflexus aurantiacus
4.3.1.19 20
-
 L-Thr Ile-insensitive enzyme Chloroflexus aurantiacus
4.3.1.19 21.3
-
 L-Thr Ile-sensitive enzyme Chloroflexus aurantiacus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.3.1.19 55000
-
 2 * 55000, SDS-PAGE Chloroflexus aurantiacus
4.3.1.19 106000
-
 gel filtration Chloroflexus aurantiacus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.1.19 L-Thr Chloroflexus aurantiacus isoleucine-insensitive enzyme is subject to glucose-mediated catabolite repression ?
-
 ?
4.3.1.19 L-Thr Chloroflexus aurantiacus Ok-79-fl isoleucine-insensitive enzyme is subject to glucose-mediated catabolite repression ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.19 Chloroflexus aurantiacus
-
-
-
4.3.1.19 Chloroflexus aurantiacus
-
 2 enzyme forms: an isoleucine-sensitive enzyme form and and an isoleucine-insensitive form
-
4.3.1.19 Chloroflexus aurantiacus Ok-79-fl
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.1.19
-
 Chloroflexus aurantiacus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.3.1.19 additional information
-
-
 Chloroflexus aurantiacus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.19 L-serine
-
 Chloroflexus aurantiacus pyruvate + NH3
-
 ?
4.3.1.19 L-serine
-
 Chloroflexus aurantiacus Ok-79-fl pyruvate + NH3
-
 ?
4.3.1.19 L-Thr isoleucine-insensitive enzyme is subject to glucose-mediated catabolite repression Chloroflexus aurantiacus ?
-
 ?
4.3.1.19 L-Thr isoleucine-insensitive enzyme is subject to glucose-mediated catabolite repression Chloroflexus aurantiacus Ok-79-fl ?
-
 ?
4.3.1.19 L-threonine
-
 Chloroflexus aurantiacus 2-oxobutanoate + NH3
-
 ?
4.3.1.19 L-threonine
-
 Chloroflexus aurantiacus Ok-79-fl 2-oxobutanoate + NH3
-
 ?

Subunits

EC Number Subunits Comment Organism
4.3.1.19 dimer 2 * 55000, SDS-PAGE Chloroflexus aurantiacus

Cofactor

EC Number Cofactor Comment Organism Structure
4.3.1.19 pyridoxal 5'-phosphate cofactor Chloroflexus aurantiacus