Any feedback?
Literature summary extracted from
- Beef-liver 5-aminolevulinic acid dehydratase (1972), Eur. J. Biochem., 29, 563-671.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.24 | thiol | required | Bos taurus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.24 | Cd2+ | inhibition at low concentration of substrate and stimulation at high levels of substrate | Bos taurus | |
| 4.2.1.24 | EDTA | - |
Bos taurus | |
| 4.2.1.24 | iodoacetamide | 1 mM, 97% inhibition | Bos taurus | |
| 4.2.1.24 | NEM | 1 mM, 85% inhibition | Bos taurus | |
| 4.2.1.24 | Pb2+ | - |
Bos taurus | |
| 4.2.1.24 | PCMB | 1 mM, 97% inhibition | Bos taurus | |
| 4.2.1.24 | Zn2+ | - |
Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.24 | 0.15 | - |
5-aminolevulinate | partially purified enzyme | Bos taurus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.24 | Cd2+ | inhibition at low concentration of substrate and stimulation at high levels of substrate | Bos taurus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.24 | 260000 | - |
low-speed equilibrium sedimentation | Bos taurus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.24 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.2.1.24 | - |
Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.2.1.24 | liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.24 | 5-aminolevulinate + 5-aminolevulinate | - |
Bos taurus | porphobilinogen + 2 H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.2.1.24 | More | - |
Bos taurus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.24 | 65 | - |
- |
Bos taurus |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.24 | 64 | - |
60 min, 20% loss of activity | Bos taurus |
| 4.2.1.24 | 80 | - |
15 min, 50% loss of activity | Bos taurus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.24 | 6.3 | - |
- |
Bos taurus |
| 4.2.1.24 | 6.3 | 6.4 | - |
Bos taurus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
