EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | arsenate | competitive inhibitor of daunorubicin transport | Homo sapiens | |
7.6.2.2 | azidophenacylglutathione | competitive inhibitor of daunorubicin transport | Homo sapiens | |
7.6.2.2 | cyclosporin A | weak competitive inhibitor of daunorubicin transport | Homo sapiens | |
7.6.2.2 | genistein | competitive inhibitor of daunorubicin transport | Homo sapiens | |
7.6.2.2 | GSH | competitive inhibitor of daunorubicin transport | Homo sapiens | |
7.6.2.2 | GSSG | competitive inhibitor of daunorubicin transport | Homo sapiens | |
7.6.2.2 | MK571 | competitive inhibitor of daunorubicin transport | Homo sapiens | |
7.6.2.2 | PSC833 | weak competitive inhibitor of daunorubicin transport | Homo sapiens | |
7.6.2.2 | verapamil | weak competitive inhibitor of daunorubicin transport | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
7.6.2.2 | 0.0055 | - |
vincristine/in | - |
Homo sapiens | |
7.6.2.2 | 0.0057 | - |
etoposide/in | - |
Homo sapiens | |
7.6.2.2 | 0.0061 | - |
daunorubicin/in | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | additional information | Homo sapiens | enzyme confers cellular resistance to a variety of natural product cytotoxic agents | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.6.2.2 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
7.6.2.2 | HEK-293 cell | - |
Homo sapiens | - |
7.6.2.2 | HL-60 cell | MRP-overexpressing HL60/ADR cells | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | daunorubicin/in + ATP + H2O | - |
Homo sapiens | daunorubicin/out + ADP + phosphate | - |
? | |
7.6.2.2 | etoposide/in + ATP + H2O | - |
Homo sapiens | etoposide/out + ADP + phosphate | - |
? | |
7.6.2.2 | additional information | enzyme confers cellular resistance to a variety of natural product cytotoxic agents | Homo sapiens | ? | - |
? | |
7.6.2.2 | vincristine/in + ATP + H2O | - |
Homo sapiens | vincristine/out + ADP + phosphate | - |
? |