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Literature summary extracted from

  • Recio, J.A.; Paez, J.G.; Maskeri, B.; Loveland, M.; Velasco, J.A.; Notario, V.
    Both normal and transforming PCPH proteins have guanosine diphosphatase activity but only the oncoprotein cooperates with ras in activating extracellular signal-regulated kinase ERK1 (2000), Cancer Res., 60, 1720-1728.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.42 normal and transforming PCPH proteins: PCPH, PCPH proto-oncogene and mt-PCPH, PCPH oncogene having guanosine diphosphatase activity Mus musculus
3.6.1.42 normal and transforming PCPH proteins: PCPH, PCPH proto-oncogene and mt-PCPH, PCPH oncogene having guanosine diphosphatase activity Homo sapiens
3.6.1.42 normal and transforming PCPH proteins: PCPH, PCPH proto-oncogene and mt-PCPH, PCPH oncogene having guanosine diphosphatase activity, expression in Escherichia coli BL21, DE3 Mesocricetus auratus

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.42 Homo sapiens
-
 normal and transforming PCPH proteins: PCPH, PCPH proto-oncogene and mt-PCPH, PCPH oncogene having guanosine diphosphatase activity
-
3.6.1.42 Mesocricetus auratus
-
 Syrian hamster, normal and transforming PCPH proteins: PCPH, PCPH proto-oncogene and mt-PCPH, PCPH oncogene having guanosine diphosphatase activity
-
3.6.1.42 Mus musculus
-
 normal and transforming PCPH proteins: PCPH, PCPH proto-oncogene and mt-PCPH, PCPH oncogene having guanosine diphosphatase activity
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.42 normal and transforming PCPH proteins: PCPH, PCPH proto-oncogene and mt-PCPH, PCPH oncogene having guanosine diphosphatase activity, recombinant proteins from Escherichia coli BL21, DE3. Purified bacterial recombinant PCPH and mt-PCPH proteins have GDPase activity Mesocricetus auratus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.42 embryo
-
 Mesocricetus auratus
-
3.6.1.42 fibroblast
-
 Mesocricetus auratus
-
3.6.1.42 kidney
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.42 GDP + H2O PCPH and mt-PCPH proteins have intrinsic GDPase activity, are GDPases Mus musculus 5'-GMP + phosphate
-
 ?
3.6.1.42 GDP + H2O PCPH and mt-PCPH proteins have intrinsic GDPase activity, are GDPases Homo sapiens 5'-GMP + phosphate
-
 ?
3.6.1.42 GDP + H2O PCPH and mt-PCPH proteins have intrinsic GDPase activity, are GDPases Mesocricetus auratus 5'-GMP + phosphate
-
 ?
3.6.1.42 IDP + H2O
-
 Mus musculus IMP + phosphate
-
 ?
3.6.1.42 IDP + H2O
-
 Homo sapiens IMP + phosphate
-
 ?
3.6.1.42 IDP + H2O
-
 Mesocricetus auratus IMP + phosphate
-
 ?
3.6.1.42 UDP + H2O
-
 Mus musculus UMP + phosphate
-
 ?
3.6.1.42 UDP + H2O
-
 Homo sapiens UMP + phosphate
-
 ?
3.6.1.42 UDP + H2O
-
 Mesocricetus auratus UMP + phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.6.1.42 37
-
 assay at Mus musculus
3.6.1.42 37
-
 assay at Homo sapiens
3.6.1.42 37
-
 assay at Mesocricetus auratus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.42 7.5
-
 assay at Mus musculus
3.6.1.42 7.5
-
 assay at Homo sapiens
3.6.1.42 7.5
-
 assay at Mesocricetus auratus