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Literature summary extracted from

  • Lazewska, D.; Starzynska, E.; Guranowski, A.
    Human placental (asymmetrical) diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase: Purification to homogenity and some properties (1993), Protein Expr. Purif., 4, 45-51.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.17 adenosine 5'-tetraphosphate Ki: 0.006 mM Homo sapiens
3.6.1.17 Ca2+ Ki: 0.3 mM Homo sapiens
3.6.1.17 diadenosine triphosphate competitive, also phosphonate analogues of the substance Homo sapiens
3.6.1.17 fluoride Ki: 0.02 mM Homo sapiens
3.6.1.17 guanosine 5'-tetraphosphate Ki: 0.01 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.17 0.01
-
 P1,P4-bis(5'-adenosyl) tetraphosphate in presence of Mg2+ Homo sapiens
3.6.1.17 0.04
-
 P1,P4-bis(5'-adenosyl) tetraphosphate in presence of Zn2+ Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.17 Co2+ 60% of activity Homo sapiens
3.6.1.17 Mg2+ maximum activity at 3 mM Homo sapiens
3.6.1.17 Mn2+ 40% of activity Homo sapiens
3.6.1.17 Zn2+ 50% of activity Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.1.17 19200
-
 SDS-PAGE, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.17 P1,P4-bis(5'-adenosyl) tetraphosphate + H2O Homo sapiens
-
 ATP + AMP
-
 ?
3.6.1.17 P1,P4-bis(5'-guanosyl)tetraphosphate + H2O Homo sapiens
-
 GTP + GMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.17 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.17
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.6.1.17 0.00022
-
 crude extract Homo sapiens
3.6.1.17 52
-
 purified enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.17 di-2,6-diaminopurine beta-D-ribofuranoside tetraphosphate + H2O
-
 Homo sapiens ?
-
 ?
3.6.1.17 P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
 Homo sapiens ATP + AMP
-
 ?
3.6.1.17 P1,P4-bis(5'-guanosyl)tetraphosphate + H2O
-
 Homo sapiens GTP + GMP
-
 ?
3.6.1.17 P1,P5-bis(5'-adenosyl) pentaphosphate + H2O
-
 Homo sapiens ADP + ATP
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.17 7.3
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.6.1.17 6.5 8.5 half maximum activity Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.6.1.17 0.01
-
 guanosine 5'-tetraphosphate
-
 Homo sapiens
3.6.1.17 0.02
-
 fluoride
-
 Homo sapiens
3.6.1.17 0.3
-
 Ca2+
-
 Homo sapiens