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Literature summary extracted from

  • Pinto, R.M.; Costas, M.J.; Fernandez, A.; Canales, J.; Garcia-Agundez, J.A.; Camselle, J.C.
    Dinucleoside tetraphosphatase from human blood cells: Purification and characterization as a high specific activity enzyme recognized by an anti-rat tetraphosphatase antibody (1991), FEBS Lett., 287, 85-88.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.17 adenosine 5'-tetraphosphate competitive; Ki in nanomolar range Homo sapiens
3.6.1.17 adenosine 5'-tetraphosphate Ki in nanomolar range Rattus norvegicus
3.6.1.17 fluoride
-
 Homo sapiens
3.6.1.17 fluoride
-
 Rattus norvegicus
3.6.1.17 Zn2+
-
 Homo sapiens
3.6.1.17 Zn2+
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.17 0.0007
-
 P1,P4-bis(5'-adenosyl) tetraphosphate
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.17 Mg2+ required, optimum concentration 3-10 mM Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.1.17 18000
-
 SDS-PAGE, immunoblot Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.17 P1,P4-bis(5'-adenosyl) tetraphosphate + H2O Homo sapiens
-
 ATP + AMP
-
 ?
3.6.1.17 P1,P4-bis(5'-adenosyl) tetraphosphate + H2O Rattus norvegicus
-
 ATP + AMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.17 Homo sapiens
-
-
-
3.6.1.17 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.17
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.17 blood
-
 Homo sapiens
-
3.6.1.17 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.6.1.17 0.0001
-
 crude extract Homo sapiens
3.6.1.17 18.5
-
 purified enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.17 P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
 Homo sapiens ATP + AMP
-
 ?
3.6.1.17 P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
 Rattus norvegicus ATP + AMP
-
 ?