BRENDA - Enzyme Database

Enzymes of pyrimidine deoxyribonucleotide metabolism in Mycoplasma mycoides subsp. mycoides

Neale, G.A.M.; Mitchell, A.; Finch, L.R.; J. Bacteriol. 156, 1001-1005 (1983)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.5.4.12
dCTP
activation, absolute requirement for dCTP
Mycoplasma mycoides
General Stability
EC Number
General Stability
Organism
3.5.4.12
highly stable enzyme
Mycoplasma mycoides
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.4.12
dTTP
allosteric inhibitor
Mycoplasma mycoides
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.5.4.12
additional information
-
additional information
preliminary kinetic studies and kinetic data
Mycoplasma mycoides
3.5.4.12
0.046
-
dCMP
-
Mycoplasma mycoides
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.4.12
dCMP + H2O
Mycoplasma mycoides
enzyme of pyrimidine deoxyribonucleotide metabolism, important for the synthesis of thymidine nucleotides from thymine. Enzyme could provide the major means of dUMP formation
dUMP + NH3
-
Mycoplasma mycoides
?
3.6.1.12
dCTP + H2O
Mycoplasma mycoides
enzyme of salvage synthesis of pyrimidine deoxyribonucleotides
dCMP + diphosphate
-
Mycoplasma mycoides
?
3.6.1.23
dUTP + H2O
Mycoplasma mycoides
enzyme of pyrimidine deoxyribonucleotide metabolism
?
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.4.14
Mycoplasma mycoides
-
subsp. mycoides
-
3.5.4.12
Mycoplasma mycoides
-
subsp. mycoides
-
3.6.1.12
Mycoplasma mycoides
-
subsp. mycoides
-
3.6.1.23
Mycoplasma mycoides
-
subsp. mycoides
-
Reaction
EC Number
Reaction
Commentary
Organism
3.5.4.12
dCMP + H2O = dUMP + NH3
highly regulated allosteric enzyme; regulation, allosteric end-product regulation
Mycoplasma mycoides
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.4.14
ATP + CMP
-
209853
Mycoplasma mycoides
ADP + CDP
-
-
-
?
2.7.4.14
ATP + dCMP
no evidence for reversal of the reaction
209853
Mycoplasma mycoides
ADP + dCDP
-
209853
Mycoplasma mycoides
?
2.7.4.14
ATP + dCMP
no evidence for reversal of the reaction
209853
Mycoplasma mycoides
ADP + dCDP
-
209853
Mycoplasma mycoides
ir
3.5.4.12
dCMP + H2O
-
209853
Mycoplasma mycoides
dUMP + NH3
-
209853
Mycoplasma mycoides
?
3.5.4.12
dCMP + H2O
enzyme of pyrimidine deoxyribonucleotide metabolism, important for the synthesis of thymidine nucleotides from thymine. Enzyme could provide the major means of dUMP formation
209853
Mycoplasma mycoides
dUMP + NH3
-
209853
Mycoplasma mycoides
?
3.6.1.12
dCTP + H2O
-
209853
Mycoplasma mycoides
dCMP + diphosphate
-
209853
Mycoplasma mycoides
?
3.6.1.12
dCTP + H2O
enzyme of salvage synthesis of pyrimidine deoxyribonucleotides
209853
Mycoplasma mycoides
dCMP + diphosphate
-
209853
Mycoplasma mycoides
?
3.6.1.23
dUTP + H2O
-
209853
Mycoplasma mycoides
dUMP + diphosphate
-
209853
Mycoplasma mycoides
?
3.6.1.23
dUTP + H2O
enzyme of pyrimidine deoxyribonucleotide metabolism
209853
Mycoplasma mycoides
?
-
-
-
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
3.5.4.12
37
-
assay at
Mycoplasma mycoides
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.5.4.12
7.8
-
assay at
Mycoplasma mycoides
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.5.4.12
dCTP
activation, absolute requirement for dCTP
Mycoplasma mycoides
General Stability (protein specific)
EC Number
General Stability
Organism
3.5.4.12
highly stable enzyme
Mycoplasma mycoides
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.4.12
dTTP
allosteric inhibitor
Mycoplasma mycoides
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.5.4.12
additional information
-
additional information
preliminary kinetic studies and kinetic data
Mycoplasma mycoides
3.5.4.12
0.046
-
dCMP
-
Mycoplasma mycoides
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.4.12
dCMP + H2O
Mycoplasma mycoides
enzyme of pyrimidine deoxyribonucleotide metabolism, important for the synthesis of thymidine nucleotides from thymine. Enzyme could provide the major means of dUMP formation
dUMP + NH3
-
Mycoplasma mycoides
?
3.6.1.12
dCTP + H2O
Mycoplasma mycoides
enzyme of salvage synthesis of pyrimidine deoxyribonucleotides
dCMP + diphosphate
-
Mycoplasma mycoides
?
3.6.1.23
dUTP + H2O
Mycoplasma mycoides
enzyme of pyrimidine deoxyribonucleotide metabolism
?
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.4.14
ATP + CMP
-
209853
Mycoplasma mycoides
ADP + CDP
-
-
-
?
2.7.4.14
ATP + dCMP
no evidence for reversal of the reaction
209853
Mycoplasma mycoides
ADP + dCDP
-
209853
Mycoplasma mycoides
?
2.7.4.14
ATP + dCMP
no evidence for reversal of the reaction
209853
Mycoplasma mycoides
ADP + dCDP
-
209853
Mycoplasma mycoides
ir
3.5.4.12
dCMP + H2O
-
209853
Mycoplasma mycoides
dUMP + NH3
-
209853
Mycoplasma mycoides
?
3.5.4.12
dCMP + H2O
enzyme of pyrimidine deoxyribonucleotide metabolism, important for the synthesis of thymidine nucleotides from thymine. Enzyme could provide the major means of dUMP formation
209853
Mycoplasma mycoides
dUMP + NH3
-
209853
Mycoplasma mycoides
?
3.6.1.12
dCTP + H2O
-
209853
Mycoplasma mycoides
dCMP + diphosphate
-
209853
Mycoplasma mycoides
?
3.6.1.12
dCTP + H2O
enzyme of salvage synthesis of pyrimidine deoxyribonucleotides
209853
Mycoplasma mycoides
dCMP + diphosphate
-
209853
Mycoplasma mycoides
?
3.6.1.23
dUTP + H2O
-
209853
Mycoplasma mycoides
dUMP + diphosphate
-
209853
Mycoplasma mycoides
?
3.6.1.23
dUTP + H2O
enzyme of pyrimidine deoxyribonucleotide metabolism
209853
Mycoplasma mycoides
?
-
-
-
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
3.5.4.12
37
-
assay at
Mycoplasma mycoides
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.5.4.12
7.8
-
assay at
Mycoplasma mycoides