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Literature summary extracted from

  • Neale, G.A.M.; Mitchell, A.; Finch, L.R.
    Enzymes of pyrimidine deoxyribonucleotide metabolism in Mycoplasma mycoides subsp. mycoides (1983), J. Bacteriol., 156, 1001-1005.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.4.12 dCTP activation, absolute requirement for dCTP Mycoplasma mycoides

General Stability

EC Number General Stability Organism
3.5.4.12 highly stable enzyme Mycoplasma mycoides

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.12 dTTP allosteric inhibitor Mycoplasma mycoides

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.12 additional information
-
 additional information preliminary kinetic studies and kinetic data Mycoplasma mycoides
3.5.4.12 0.046
-
 dCMP
-
 Mycoplasma mycoides

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.12 dCMP + H2O Mycoplasma mycoides enzyme of pyrimidine deoxyribonucleotide metabolism, important for the synthesis of thymidine nucleotides from thymine. Enzyme could provide the major means of dUMP formation dUMP + NH3
-
 ?
3.6.1.12 dCTP + H2O Mycoplasma mycoides enzyme of salvage synthesis of pyrimidine deoxyribonucleotides dCMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O Mycoplasma mycoides enzyme of pyrimidine deoxyribonucleotide metabolism ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.14 Mycoplasma mycoides
-
 subsp. mycoides
-
3.5.4.12 Mycoplasma mycoides
-
 subsp. mycoides
-
3.6.1.12 Mycoplasma mycoides
-
 subsp. mycoides
-
3.6.1.23 Mycoplasma mycoides
-
 subsp. mycoides
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.5.4.12 dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Mycoplasma mycoides
a
3.5.4.12 dCMP + H2O = dUMP + NH3 highly regulated allosteric enzyme Mycoplasma mycoides
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.14 ATP + CMP
-
 Mycoplasma mycoides ADP + CDP
-
 ?
2.7.4.14 ATP + dCMP no evidence for reversal of the reaction Mycoplasma mycoides ADP + dCDP
-
 ?
2.7.4.14 ATP + dCMP no evidence for reversal of the reaction Mycoplasma mycoides ADP + dCDP
-
 ir
3.5.4.12 dCMP + H2O
-
 Mycoplasma mycoides dUMP + NH3
-
 ?
3.5.4.12 dCMP + H2O enzyme of pyrimidine deoxyribonucleotide metabolism, important for the synthesis of thymidine nucleotides from thymine. Enzyme could provide the major means of dUMP formation Mycoplasma mycoides dUMP + NH3
-
 ?
3.6.1.12 dCTP + H2O
-
 Mycoplasma mycoides dCMP + diphosphate
-
 ?
3.6.1.12 dCTP + H2O enzyme of salvage synthesis of pyrimidine deoxyribonucleotides Mycoplasma mycoides dCMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O
-
 Mycoplasma mycoides dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O enzyme of pyrimidine deoxyribonucleotide metabolism Mycoplasma mycoides ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.4.12 37
-
 assay at Mycoplasma mycoides

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.12 7.8
-
 assay at Mycoplasma mycoides