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Literature summary extracted from

  • Guranowski, A.; Starzynska, E.; Barnes, L.D.; Robinson, A.K.; Liu, S.
    Adenosine 5'-tetraphosphate phosphohydrolase activity is an inherent property of soluble exopolyphosphatase from yeast Saccharomyces cerevisiae (1998), Biochim. Biophys. Acta, 1380, 232-238.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.11 Ammonium molybdate
-
 Saccharomyces cerevisiae
3.6.1.11 o-vanadate
-
 Saccharomyces cerevisiae
3.6.1.11 ZnCl2
-
 Saccharomyces cerevisiae
3.6.1.14 Ammonium molybdate
-
 Saccharomyces cerevisiae
3.6.1.14 sodium o-vanadate
-
 Saccharomyces cerevisiae
3.6.1.14 Zn2+ ZnCl2 Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.11 0.08
-
 adenosine 5'-tetraphosphate at pH 4.8, 50 mM sodium acetate, 5 mM CoCl2 Saccharomyces cerevisiae
3.6.1.14 0.08
-
 adenosine 5'-tetraphosphate pH 4.75, 50 mM sodium acetate, 5 mM CoCl2 Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.11 Co2+ divalent cation required, order of decreasing stimulation: Co2+, Mn2+, Mg2+, Ni2+ Saccharomyces cerevisiae
3.6.1.11 Mg2+ divalent cation required, order of decreasing stimulation: Co2+, Mn2+, Mg2+, Ni2+ Saccharomyces cerevisiae
3.6.1.11 Mn2+ divalent cation required, order of decreasing stimulation: Co2+, Mn2+, Mg2+, Ni2+ Saccharomyces cerevisiae
3.6.1.11 Ni2+ divalent cation required, order of decreasing stimulation: Co2+, Mn2+, Mg2+, Ni2+ Saccharomyces cerevisiae
3.6.1.14 Co2+ divalent cations activate hydrolysis of adenosine 5'-tetraphosphate in the order of decreasing effectiveness: Co2+, Mn2+, Mg2+, Ni2+ Saccharomyces cerevisiae
3.6.1.14 Mg2+ divalent cations activate hydrolysis of adenosine 5'-tetraphosphate in the order of decreasing effectiveness: Co2+, Mn2+, Mg2+, Ni2+ Saccharomyces cerevisiae
3.6.1.14 Mn2+ divalent cations activate hydrolysis of adenosine 5'-tetraphosphate in the order of decreasing effectiveness: Co2+, Mn2+, Mg2+, Ni2+ Saccharomyces cerevisiae
3.6.1.14 Ni2+ divalent cations activate hydrolysis of adenosine 5'-tetraphosphate in the order of decreasing effectiveness: Co2+, Mn2+, Mg2+, Ni2+ Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.1.14 45000
-
 x * 45000, SDS-PAGE Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.11 Saccharomyces cerevisiae
-
-
-
3.6.1.14 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.11 (polyphosphate)n + H2O
-
 Saccharomyces cerevisiae (polyphosphate)n-1 + phosphate
-
 ?
3.6.1.11 adenosine 5'-pentaphosphate + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
3.6.1.11 adenosine 5'-tetraphosphate + H2O
-
 Saccharomyces cerevisiae ATP + phosphate
-
 ?
3.6.1.11 guanosine-5'-tetraphosphate + H2O
-
 Saccharomyces cerevisiae GTP + phosphate
-
 ?
3.6.1.11 inosine tetraphosphate + H2O
-
 Saccharomyces cerevisiae ITP + phosphate
-
 ?
3.6.1.14 adenosine 5'-pentaphosphate + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
3.6.1.14 adenosine 5'-tetraphosphate + H2O
-
 Saccharomyces cerevisiae ATP + phosphate
-
 ?
3.6.1.14 guanosine tetraphosphate + H2O
-
 Saccharomyces cerevisiae GTP + phosphate
-
 ?
3.6.1.14 inosine tetraphosphate + H2O
-
 Saccharomyces cerevisiae ITP + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.1.14 ? x * 45000, SDS-PAGE Saccharomyces cerevisiae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.6.1.11 40
-
 adenosine-5'-pentaphosphate
-
 Saccharomyces cerevisiae
3.6.1.11 723
-
 adenosine 5'-tetraphosphate
-
 Saccharomyces cerevisiae
3.6.1.14 40
-
 adenosine-5'-pentaphosphate
-
 Saccharomyces cerevisiae
3.6.1.14 723
-
 adenosine 5'-tetraphosphate
-
 Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.11 4.8
-
 in presence of Co2+ Saccharomyces cerevisiae
3.6.1.14 4.8
-
-
 Saccharomyces cerevisiae

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.6.1.11 3.8 7.2 50% of maximal activity at pH 3.8 and at pH 7.2 Saccharomyces cerevisiae
3.6.1.14 3.8 7.2 50% of maximal activity at pH 3.8 and 7.2 Saccharomyces cerevisiae