EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.5 | phosphate | effect on the NAD+-dependent dehydrogenase activity | Photobacterium phosphoreum | |
3.5.4.9 | phosphate | - |
Homo sapiens | |
3.5.4.9 | phosphate | - |
Photobacterium phosphoreum |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.5.1.5 | expressed in Escherichia coli | Photobacterium phosphoreum |
3.5.4.9 | amplified genomic library transformed into yest YA3-1, yeast-DNA transformed into Escherichia coli K38 pBKe, gene folD encoding PPDC expressed | Photobacterium phosphoreum |
3.5.4.9 | bifunctional dehydrogenase/cyclohydrolase portion of the cytoplasmic trifunctional enzyme cloned and heterologous expressed in the yeast strain YA3-1 | Homo sapiens |
3.5.4.9 | cDNA encoding trifunctional enzyme used to complete the purine auxotrophic yeast strain YA3-1 | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.5 | potassium phosphate | effect on NADP+-dependent dehydrogenase activity | Photobacterium phosphoreum | |
1.5.1.5 | potassium sulfate | effect on NADP+-dependent dehydrogenase activity | Photobacterium phosphoreum |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.5 | 0.0011 | - |
5,10-methylenetetrahydrofolate | cofactor: NADP+ | Photobacterium phosphoreum | |
1.5.1.5 | 0.016 | - |
5,10-methylenetetrahydrofolate | cofactor: NAD+ | Photobacterium phosphoreum | |
1.5.1.5 | 0.2 | - |
NADP+ | - |
Photobacterium phosphoreum | |
1.5.1.5 | 4.76 | - |
5,10-methylenetetrahydrofolate | - |
Photobacterium phosphoreum | |
3.5.4.9 | 0.031 | - |
(6R,S)-methenyltetrahydrofolate | - |
Photobacterium phosphoreum |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.5.1.5 | 31000 | - |
x * 31000, SDS-PAGE | Photobacterium phosphoreum |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.5 | 5,10-methylenetetrahydrofolate + NADP+ | Photobacterium phosphoreum | - |
5,10-methenyltetrahydrofolate + NADPH + H+ | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | Salmonella enterica subsp. enterica serovar Typhimurium | - |
10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | Drosophila melanogaster | - |
10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | Mus musculus | - |
10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | Escherichia coli | - |
10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | Homo sapiens | - |
10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | Rattus norvegicus | - |
10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | Saccharomyces cerevisiae | - |
10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | Photobacterium phosphoreum | - |
10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | Clostridium formicaceticum | - |
10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | Spodoptera frugiperda | - |
10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | Acetobacterium woodii | - |
10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | Spodoptera frugiperda Sf9 | - |
10-formyltetrahydrofolate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.5 | Photobacterium phosphoreum | - |
- |
- |
3.5.4.9 | Acetobacterium woodii | - |
bifunctional enzyme | - |
3.5.4.9 | Clostridium formicaceticum | - |
ATCC 23439, monofunctional enzyme | - |
3.5.4.9 | Drosophila melanogaster | - |
- |
- |
3.5.4.9 | Escherichia coli | - |
- |
- |
3.5.4.9 | Homo sapiens | - |
human, bifunctional mitochondrial enzyme, trifunctional cytoplasmic enzyme | - |
3.5.4.9 | Mus musculus | - |
mouse, bifunctional mitochondrial enzyme | - |
3.5.4.9 | Photobacterium phosphoreum | - |
marine bioluminescent bacterium, bifunctional enzyme | - |
3.5.4.9 | Rattus norvegicus | - |
rat, trifunctional cytoplasmic enzyme | - |
3.5.4.9 | Saccharomyces cerevisiae | - |
cytoplasmic, mitochondrial | - |
3.5.4.9 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
3.5.4.9 | Spodoptera frugiperda | - |
- |
- |
3.5.4.9 | Spodoptera frugiperda Sf9 | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.5.1.5 | bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase | Photobacterium phosphoreum |
3.5.4.9 | recombinant protein expressed in Escherichia coli K38 | Photobacterium phosphoreum |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.5.1.5 | 97.4 | - |
recombinant bifunctional enzyme | Photobacterium phosphoreum |
3.5.4.9 | 97.4 | - |
recombinant enzyme | Photobacterium phosphoreum |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.5 | 5,10-methylenetetrahydrofolate + NAD+ | - |
Photobacterium phosphoreum | 5,10-methenyltetrahydrofolate + NADH + H+ | - |
r | |
1.5.1.5 | 5,10-methylenetetrahydrofolate + NADP+ | - |
Photobacterium phosphoreum | 5,10-methenyltetrahydrofolate + NADPH + H+ | - |
? | |
3.5.4.9 | (6R,S)-methenyltetrahydrofolate + H2O | - |
Homo sapiens | ? | - |
? | |
3.5.4.9 | (6R,S)-methenyltetrahydrofolate + H2O | - |
Photobacterium phosphoreum | ? | - |
r | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | - |
Drosophila melanogaster | 10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | - |
Mus musculus | 10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | - |
Escherichia coli | 10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | - |
Homo sapiens | 10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | - |
Rattus norvegicus | 10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | - |
Saccharomyces cerevisiae | 10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | - |
Photobacterium phosphoreum | 10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | - |
Clostridium formicaceticum | 10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | - |
Spodoptera frugiperda | 10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | - |
Acetobacterium woodii | 10-formyltetrahydrofolate | - |
? | |
3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | - |
Spodoptera frugiperda Sf9 | 10-formyltetrahydrofolate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.5.1.5 | ? | x * 31000, SDS-PAGE | Photobacterium phosphoreum |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.5 | 113 | - |
NADP+ | - |
Photobacterium phosphoreum | |
1.5.1.5 | 136 | - |
NAD+ | - |
Photobacterium phosphoreum |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.5 | NAD+ | NADP+ preferred cofactor in vivo | Photobacterium phosphoreum | |
1.5.1.5 | NADP+ | - |
Photobacterium phosphoreum |