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Literature summary extracted from
- On the role of cytidine deaminase in cellular metabolism (1986), Adv. Exp. Med. Biol., 195B, 415-420.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.4.5 | cytidine | - |
Salmonella enterica subsp. enterica serovar Typhimurium |  |
| 3.5.4.5 | cytidine | - |
Escherichia coli | |
| 3.5.4.5 | uridine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.5.4.5 | medicine | different effect of cytidine in blood cells from healthy donors and chronic lymphocytic and acute myeloblastic leukemia patients | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.5 | cytidine + H2O | Salmonella enterica subsp. enterica serovar Typhimurium | - |
uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | Mus musculus | - |
uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | Escherichia coli | - |
uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | Homo sapiens | - |
uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | Saccharomyces cerevisiae | - |
uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | Ovis aries | - |
uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | Zea mays | - |
uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | Mus musculus BALB/c | - |
uridine + NH3 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.4.5 | Escherichia coli | - |
- |
- |
| 3.5.4.5 | Homo sapiens | - |
human | - |
| 3.5.4.5 | Homo sapiens | - |
hematopoietic cell lines | - |
| 3.5.4.5 | Mus musculus | - |
mouse | - |
| 3.5.4.5 | Mus musculus | - |
BALB/c | - |
| 3.5.4.5 | Mus musculus BALB/c | - |
BALB/c | - |
| 3.5.4.5 | no activity in Lactobacillus sp. | - |
- |
- |
| 3.5.4.5 | no activity in Moraxella sp. | - |
- |
- |
| 3.5.4.5 | no activity in Pseudomonas sp. | - |
- |
- |
| 3.5.4.5 | Ovis aries | - |
- |
- |
| 3.5.4.5 | Saccharomyces cerevisiae | - |
- |
- |
| 3.5.4.5 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
| 3.5.4.5 | Zea mays | - |
corn | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.5.4.5 | - |
Saccharomyces cerevisiae |
| 3.5.4.5 | - |
Zea mays |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.4.5 | granulocyte | - |
Homo sapiens | - |
| 3.5.4.5 | kidney | - |
Mus musculus | - |
| 3.5.4.5 | kidney | - |
Homo sapiens | - |
| 3.5.4.5 | leukocyte | - |
Homo sapiens | - |
| 3.5.4.5 | liver | - |
Mus musculus | - |
| 3.5.4.5 | liver | - |
Homo sapiens | - |
| 3.5.4.5 | liver | - |
Ovis aries | - |
| 3.5.4.5 | marrow | - |
Homo sapiens | - |
| 3.5.4.5 | spleen | - |
Mus musculus | - |
| 3.5.4.5 | spleen | - |
Homo sapiens | - |
| 3.5.4.5 | thymocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.5 | 5'-fluoro-5'-deoxycytidine + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 5'-fluoro-5'-deoxyuridine + NH3 | - |
? | |
| 3.5.4.5 | 5'-fluoro-5'-deoxycytidine + H2O | - |
Escherichia coli | 5'-fluoro-5'-deoxyuridine + NH3 | - |
? | |
| 3.5.4.5 | 5-azacytidine + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 5-azauridine + NH3 | - |
? | |
| 3.5.4.5 | 5-azacytidine + H2O | - |
Escherichia coli | 5-azauridine + NH3 | - |
? | |
| 3.5.4.5 | 5-azacytidine + H2O | - |
Homo sapiens | 5-azauridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | - |
Mus musculus | uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | - |
Escherichia coli | uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | - |
Homo sapiens | uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | - |
Saccharomyces cerevisiae | uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | - |
Ovis aries | uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | - |
Zea mays | uridine + NH3 | - |
? | |
| 3.5.4.5 | cytidine + H2O | - |
Mus musculus BALB/c | uridine + NH3 | - |
? | |
| 3.5.4.5 | cytosine arabinoside + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | uridine arabinoside + NH3 | - |
? | |
| 3.5.4.5 | cytosine arabinoside + H2O | - |
Mus musculus | uridine arabinoside + NH3 | - |
? | |
| 3.5.4.5 | cytosine arabinoside + H2O | - |
Escherichia coli | uridine arabinoside + NH3 | - |
? | |
| 3.5.4.5 | cytosine arabinoside + H2O | - |
Homo sapiens | uridine arabinoside + NH3 | - |
? | |
| 3.5.4.5 | cytosine arabinoside + H2O | - |
Mus musculus BALB/c | uridine arabinoside + NH3 | - |
? | |
| 3.5.4.5 | deoxycytidine + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | deoxyuridine + NH3 | - |
? | |
| 3.5.4.5 | deoxycytidine + H2O | - |
Mus musculus | deoxyuridine + NH3 | - |
? | |
| 3.5.4.5 | deoxycytidine + H2O | - |
Escherichia coli | deoxyuridine + NH3 | - |
? | |
| 3.5.4.5 | deoxycytidine + H2O | - |
Homo sapiens | deoxyuridine + NH3 | - |
? | |
| 3.5.4.5 | deoxycytidine + H2O | - |
Mus musculus BALB/c | deoxyuridine + NH3 | - |
? | |
| 3.5.4.5 | additional information | cytosine and cytosine nucleotides are no substrates | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| 3.5.4.5 | additional information | cytosine and cytosine nucleotides are no substrates | Escherichia coli | ? | - |
? | |
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