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Literature summary extracted from

  • Hough, R.F.; Bass, B.L.
    Purification of the Xenopus laevis double-stranded RNA adenosine deaminase (1994), J. Biol. Chem., 269, 9933-9939.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.4 basic histone proteins
-
Xenopus laevis
3.5.4.4 heparin
-
Xenopus laevis
3.5.4.4 K+
-
Xenopus laevis
3.5.4.4 lysozyme
-
Xenopus laevis
3.5.4.4 Na+
-
Xenopus laevis
3.5.4.4 NH4+
-
Xenopus laevis
3.5.4.4 spermidine
-
Xenopus laevis
3.5.4.4 thiol reagents
-
Xenopus laevis
3.5.4.37 ammonium acetate 0.4 M, complete inhibition Xenopus laevis
3.5.4.37 Basic proteins histones and lysozyme, 0.5 mg/ml, complete inhibition Xenopus laevis
3.5.4.37 Double-stranded RNA excess of substrate inhibits Xenopus laevis
3.5.4.37 heparin 0.5 mg/ml, complete inhibition Xenopus laevis
3.5.4.37 iodoacetate 10 mM, complete inhibition Xenopus laevis
3.5.4.37 KCl 0.2 M, complete inhibition Xenopus laevis
3.5.4.37 additional information no inhibition: DNA (salmon sperm, 0.3 mg/ml), RNA (torula yeast, 0.3 mg/ml), acidic proteins (bovine serum albumin and casein, 2.0 mg/ml), polyglutamic acid (2.0 mg/ml), glutamic acid (2 mM), glutamine (2 mM), glyceraldehyde 6-phosphate (2 mM), CaCl2 (5.0 mM), MgCl2 (5.0 mM), EDTA (10 mM), EGTA (10 mM), ATP (10 mM), GTP (10 mM), 5'-AMP (10 mM), adenosine (10 mM), hypoxanthine (10 mM) Xenopus laevis
3.5.4.37 N-ethylmaleimide 10 mM, complete inhibition Xenopus laevis
3.5.4.37 NaCl 0.2 M, complete inhibition Xenopus laevis
3.5.4.37 potassium phosphate
-
Xenopus laevis
3.5.4.37 Sodium phosphate
-
Xenopus laevis
3.5.4.37 spermidine 0.5 mg/ml, complete inhibition Xenopus laevis
3.5.4.37 TLCK 1 mM, complete inhibition Xenopus laevis
3.5.4.37 ZnCl2 1 mM, complete inhibition Xenopus laevis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.4 90000
-
HPLC Xenopus laevis
3.5.4.4 120000
-
SDS-PAGE Xenopus laevis
3.5.4.37 12000
-
x * 12000, the purified monomeric enzyme form is active, but it is not known if the enzyme functions strictly as a monomer, it may dimerize in the presence of substrate or associate in crude mixture with other cellular constituents, SDS-PAGE Xenopus laevis
3.5.4.37 120000
-
gel filtration Xenopus laevis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.37 adenine in double-stranded RNA + H2O Xenopus laevis
-
hypoxanthine in double-stranded RNA + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.4 Xenopus laevis
-
-
-
3.5.4.37 Xenopus laevis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.4
-
Xenopus laevis
3.5.4.37
-
Xenopus laevis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.37 egg
-
Xenopus laevis
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.4 0.12
-
-
Xenopus laevis
3.5.4.37 0.002
-
25°C, pH 7.9 Xenopus laevis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.4 double-stranded RNA + H2O
-
Xenopus laevis ?
-
?
3.5.4.37 adenine in double-stranded RNA + H2O
-
Xenopus laevis hypoxanthine in double-stranded RNA + NH3
-
?

Subunits

EC Number Subunits Comment Organism
3.5.4.37 ? x * 12000, the purified monomeric enzyme form is active, but it is not known if the enzyme functions strictly as a monomer, it may dimerize in the presence of substrate or associate in crude mixture with other cellular constituents, SDS-PAGE Xenopus laevis

Synonyms

EC Number Synonyms Comment Organism
3.5.4.37 double-stranded RNA adenosine deaminase
-
Xenopus laevis
3.5.4.37 dsRAD
-
Xenopus laevis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.4 6 8.5
-
Xenopus laevis
3.5.4.37 6 8.5 Tris or phosphate buffer Xenopus laevis