EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.4.3 | 5-aminoimidazole-4-carboxamide | 29% inhibition | Homo sapiens | |
3.5.4.3 | 5-aminoimidazole-4-carboxamide | - |
Oryctolagus cuniculus | |
3.5.4.3 | 5-aminoimidazole-4-carboxamide | - |
Rattus norvegicus | |
3.5.4.3 | adenine | - |
Homo sapiens | |
3.5.4.3 | adenosine | - |
Homo sapiens | |
3.5.4.3 | hypoxanthine | slight inhibition of 8% | Homo sapiens | |
3.5.4.3 | Inosine | slight inhibition of 5% | Homo sapiens | |
3.5.4.3 | p-hydroxymercuribenzoate | noncompetitive inhibitor, 0.1 mM, 37°C, rapid inactivation | Homo sapiens | |
3.5.4.3 | p-hydroxymercuribenzoate | - |
Oryctolagus cuniculus | |
3.5.4.3 | p-hydroxymercuribenzoate | - |
Rattus norvegicus | |
3.5.4.3 | xanthine | - |
Homo sapiens | |
3.5.4.3 | Xanthosine | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.4.3 | 0.0074 | - |
guanine | at pH 8 | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.5.4.3 | cytosol | - |
Homo sapiens | 5829 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.5.4.3 | 55000 | - |
- |
Homo sapiens |
3.5.4.3 | 55000 | - |
liver, single polypeptide chain, gel filtration | Rattus norvegicus |
3.5.4.3 | 55000 | - |
liver, single polypeptide chain, gel filtration | Oryctolagus cuniculus |
3.5.4.3 | 100000 | - |
- |
Oryctolagus cuniculus |
3.5.4.3 | 100000 | - |
gel filtration | Homo sapiens |
3.5.4.3 | 110000 | - |
- |
Rattus norvegicus |
3.5.4.3 | 110000 | - |
liver, gel filtration | Homo sapiens |
3.5.4.3 | 110000 | - |
liver, gel filtration | Oryctolagus cuniculus |
3.5.4.3 | 220000 | - |
gel filtration without mercaptoethanol | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.4.3 | guanine + H2O | Homo sapiens | - |
xanthine + NH3 | - |
ir | |
3.5.4.3 | guanine + H2O | Rattus norvegicus | - |
xanthine + NH3 | - |
ir | |
3.5.4.3 | guanine + H2O | Oryctolagus cuniculus | - |
xanthine + NH3 | - |
ir |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.4.3 | Homo sapiens | - |
human | - |
3.5.4.3 | Oryctolagus cuniculus | - |
rabbit | - |
3.5.4.3 | Rattus norvegicus | - |
rat | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.5.4.3 | - |
Homo sapiens |
3.5.4.3 | - |
Oryctolagus cuniculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.4.3 | liver | - |
Homo sapiens | - |
3.5.4.3 | liver | - |
Rattus norvegicus | - |
3.5.4.3 | liver | - |
Oryctolagus cuniculus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.5.4.3 | 8.61 | - |
- |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.4.3 | 8-azaguanine + H2O | - |
Rattus norvegicus | 8-azaxanthine + NH3 | - |
? | |
3.5.4.3 | 8-azaguanine + H2O | - |
Oryctolagus cuniculus | 8-azaxanthine + NH3 | - |
? | |
3.5.4.3 | 8-azaguanine + H2O | high substrate specificity, only 60% of the reaction rate with the natural substrate guanine | Homo sapiens | 8-azaxanthine + NH3 | - |
? | |
3.5.4.3 | adenine + H2O | - |
Homo sapiens | allopurinol + NH3 | - |
? | |
3.5.4.3 | adenosine + H2O | - |
Homo sapiens | inosine + NH3 | - |
? | |
3.5.4.3 | AMP + H2O | - |
Homo sapiens | IMP + NH3 | - |
? | |
3.5.4.3 | GMP + H2O | - |
Homo sapiens | XMP + NH3 | - |
? | |
3.5.4.3 | guanine + H2O | - |
Homo sapiens | xanthine + NH3 | - |
ir | |
3.5.4.3 | guanine + H2O | - |
Rattus norvegicus | xanthine + NH3 | - |
ir | |
3.5.4.3 | guanine + H2O | - |
Oryctolagus cuniculus | xanthine + NH3 | - |
ir | |
3.5.4.3 | guanosine + H2O | - |
Homo sapiens | xanthosine + NH3 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.5.4.3 | dimer | - |
Homo sapiens |
3.5.4.3 | dimer | - |
Oryctolagus cuniculus |
3.5.4.3 | dimer | 2 * 55000, 2 or 3 isoenzymes, polymeric nature, enzyme exists as monomer, dimer or tetramer | Rattus norvegicus |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.5.4.3 | 60 | - |
50% activity lost during 30 min incubation, after 60 min 40% activity remains | Homo sapiens |
3.5.4.3 | 60 | - |
30 min incubation, liver enzyme completely inactivated | Rattus norvegicus |
3.5.4.3 | 60 | - |
30 min incubation, liver enzyme completely inactivated | Oryctolagus cuniculus |
3.5.4.3 | 65 | - |
activity completely lost after 30 min incubation | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.5.4.3 | 6.8 | - |
- |
Oryctolagus cuniculus |
3.5.4.3 | 7.5 | 9.5 | - |
Rattus norvegicus |
3.5.4.3 | 7.5 | 9.5 | - |
Oryctolagus cuniculus |
3.5.4.3 | 7.5 | 9.5 | beyond pH 9.5 activity decreases abruptly | Homo sapiens |
3.5.4.3 | 8 | - |
- |
Homo sapiens |
3.5.4.3 | 8 | - |
- |
Rattus norvegicus |
3.5.4.3 | 8 | - |
- |
Oryctolagus cuniculus |
3.5.4.3 | 8.5 | - |
- |
Rattus norvegicus |
3.5.4.3 | 8.5 | - |
- |
Oryctolagus cuniculus |
3.5.4.3 | 8.6 | - |
- |
Oryctolagus cuniculus |
3.5.4.3 | 9 | - |
- |
Homo sapiens |