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Literature summary extracted from

  • Kimm, S.W.; Park, J.B.; Kim, H.L.
    The physicochemical properties of guanine aminohydrolase purified from human liver (1987), Korean J. Biochem., 19, 39-46.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.3 5-aminoimidazole-4-carboxamide AICA, competitive inhibition Homo sapiens
3.5.4.3 5-aminoimidazole-4-carboxamide AICA, competitive inhibition Oryctolagus cuniculus
3.5.4.3 5-aminoimidazole-4-carboxamide AICA, competitive inhibition Rattus norvegicus
3.5.4.3 F- inhibition decreases as pH increases, 50% activity was inhibited at pH 7.5, most of activity lost at pH 6.5 Homo sapiens
3.5.4.3 F- inhibition decreases as pH increases, 50% activity was inhibited at pH 7.5, most of activity lost at pH 6.5 Oryctolagus cuniculus
3.5.4.3 hypoxanthine
-
 Homo sapiens
3.5.4.3 Inosine
-
 Homo sapiens
3.5.4.3 p-hydroxymercuribenzoate
-
 Homo sapiens
3.5.4.3 p-hydroxymercuribenzoate
-
 Oryctolagus cuniculus
3.5.4.3 p-hydroxymercuribenzoate
-
 Rattus norvegicus
3.5.4.3 Rose bengal photo-oxidation, 0.00025% at acidic pH Homo sapiens
3.5.4.3 Rose bengal photo-oxidation, 0.00025% at acidic pH Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.3 0.0074
-
 guanine
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.3 55000
-
 SDS-PAGE Homo sapiens
3.5.4.3 55000
-
 liver, single polypeptide chain, gel filtration Rattus norvegicus
3.5.4.3 55000
-
 liver, single polypeptide chain, gel filtration Oryctolagus cuniculus
3.5.4.3 55000
-
 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Sus sp.
3.5.4.3 110000
-
 liver, gel filtration Homo sapiens
3.5.4.3 110000
-
 liver, gel filtration Oryctolagus cuniculus
3.5.4.3 110000
-
 lung Rattus norvegicus
3.5.4.3 110000
-
 brain, gel filtration Sus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.3 guanine + H2O Homo sapiens
-
 xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O Rattus norvegicus
-
 xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O Oryctolagus cuniculus
-
 xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O Sus sp.
-
 xanthine + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.3 Homo sapiens
-
 human
-
3.5.4.3 Oryctolagus cuniculus
-
 rabbit
-
3.5.4.3 Rattus norvegicus
-
 rat
-
3.5.4.3 Sus sp.
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.3
-
 Homo sapiens
3.5.4.3
-
 Rattus norvegicus
3.5.4.3
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.3 brain
-
 Homo sapiens
-
3.5.4.3 brain
-
 Rattus norvegicus
-
3.5.4.3 brain
-
 Oryctolagus cuniculus
-
3.5.4.3 brain
-
 Sus sp.
-
3.5.4.3 liver
-
 Homo sapiens
-
3.5.4.3 liver
-
 Rattus norvegicus
-
3.5.4.3 liver
-
 Oryctolagus cuniculus
-
3.5.4.3 lung
-
 Homo sapiens
-
3.5.4.3 lung
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.3 22.1
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.3 guanine + H2O
-
 Homo sapiens xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O
-
 Rattus norvegicus xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O
-
 Oryctolagus cuniculus xanthine + NH3
-
 ?
3.5.4.3 guanine + H2O
-
 Sus sp. xanthine + NH3
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.4.3 dimer
-
 Rattus norvegicus
3.5.4.3 dimer 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Homo sapiens
3.5.4.3 dimer 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Oryctolagus cuniculus
3.5.4.3 dimer 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Sus sp.
3.5.4.3 monomer
-
 Oryctolagus cuniculus
3.5.4.3 monomer liver enzyme Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
3.5.4.3 GAH
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.3 7.5 9.5
-
 Homo sapiens
3.5.4.3 7.5 9.5
-
 Rattus norvegicus
3.5.4.3 7.5 9.5
-
 Oryctolagus cuniculus
3.5.4.3 9
-
-
 Homo sapiens
3.5.4.3 9
-
-
 Sus sp.

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.5.4.3 5 10.5
-
 Homo sapiens