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Literature summary extracted from

  • Yoo, J.C.; Han, J.M.; Ko, O.H.; Bang, H.J.
    Purification and characterization of GTP cyclohydrolase I from Streptomyces tubercidicus, a producer of tubercidin (1998), Arch. Pharm. Res., 21, 692-697.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.16 Ca2+
-
 Streptomyces tubercidicus
3.5.4.16 Co2+
-
 Streptomyces tubercidicus
3.5.4.16 CTP
-
 Streptomyces tubercidicus
3.5.4.16 Cu2+
-
 Streptomyces tubercidicus
3.5.4.16 Fe2+
-
 Streptomyces tubercidicus
3.5.4.16 GDP
-
 Streptomyces tubercidicus
3.5.4.16 GMP
-
 Streptomyces tubercidicus
3.5.4.16 K+
-
 Streptomyces tubercidicus
3.5.4.16 Mg2+
-
 Streptomyces tubercidicus
3.5.4.16 Mn2+
-
 Streptomyces tubercidicus
3.5.4.16 Na+
-
 Streptomyces tubercidicus
3.5.4.16 Ni2+
-
 Streptomyces tubercidicus
3.5.4.16 UTP
-
 Streptomyces tubercidicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.16 0.08
-
 GTP
-
 Streptomyces tubercidicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.16 58000
-
 4 * 58000, SDS-PAGE Streptomyces tubercidicus
3.5.4.16 230000
-
 gel filtration Streptomyces tubercidicus

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.16 Streptomyces tubercidicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.16
-
 Streptomyces tubercidicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.16 9.1
-
-
 Streptomyces tubercidicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.16 GTP + H2O
-
 Streptomyces tubercidicus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.4.16 tetramer 4 * 58000, SDS-PAGE Streptomyces tubercidicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.4.16 40 42
-
 Streptomyces tubercidicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.16 7.5 8.5
-
 Streptomyces tubercidicus