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Literature summary extracted from
- The enzymatic cleavage of the carbon-nitrogen bond in 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine (1967), J. Biol. Chem., 242, 7-11.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.24 | 3,7,12-triketo-5beta-cholan-24-oylglycine | - |
Clostridium perfringens |  |
| 3.5.1.24 | 3,7,12-Triketo-5beta-cholanoic acid | - |
Clostridium perfringens | |
| 3.5.1.24 | cholic acid | competitive product inhibition | Clostridium perfringens | |
| 3.5.1.24 | Cu2+ | 0.3 mM, 45% inhibition | Clostridium perfringens | |
| 3.5.1.24 | Hg2+ | 0.0001 mM, 67% inhibition | Clostridium perfringens | |
| 3.5.1.24 | iodoacetate | - |
Clostridium perfringens | |
| 3.5.1.24 | PCMB | - |
Clostridium perfringens | |
| 3.5.1.24 | Zn2+ | 5 mM, 69% inhibition | Clostridium perfringens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.1.24 | 1.2 | - |
glycodeoxycholic acid | - |
Clostridium perfringens | |
| 3.5.1.24 | 3 | - |
taurochenodeoxycholic acid | - |
Clostridium perfringens | |
| 3.5.1.24 | 3.5 | - |
taurodeoxycholic acid | - |
Clostridium perfringens | |
| 3.5.1.24 | 3.6 | - |
glycocholic acid | - |
Clostridium perfringens | |
| 3.5.1.24 | 8 | - |
glycocholic acid | - |
Clostridium perfringens | |
| 3.5.1.24 | 14 | - |
glycochenodeoxycholic acid | - |
Clostridium perfringens | |
| 3.5.1.24 | 37 | - |
taurocholic acid | - |
Clostridium perfringens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.24 | Clostridium perfringens | - |
ATCC 19574, Sinai No. 43-F-4 | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.24 | 599.2 | - |
- |
Clostridium perfringens |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.5.1.24 | -20°C, pH 7.0, stable for 8 weeks | Clostridium perfringens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.24 | 3alpha,7alpha,12alpha-trihydroxy-5beta-homocholan-24-oyltaurine + H2O | - |
Clostridium perfringens | 3alpha,7alpha,12alpha-trihydroxy-5beta-homocholanate + taurine | - |
? | |
| 3.5.1.24 | glycochenodeoxycholic acid + H2O | - |
Clostridium perfringens | 3alpha,7alpha-dihydroxy-5beta-cholanate + Gly | - |
? | |
| 3.5.1.24 | glycocholic acid + H2O | - |
Clostridium perfringens | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + glycine | - |
? | |
| 3.5.1.24 | glycodeoxycholic acid + H2O | - |
Clostridium perfringens | 3alpha,12alpha-dihydroxy-5beta-cholanate + Gly | - |
? | |
| 3.5.1.24 | taurochenodeoxycholic acid + H2O | - |
Clostridium perfringens | 3alpha,7alpha-dihydroxy-5beta-cholanate + taurine | - |
? | |
| 3.5.1.24 | taurocholic acid + H2O | - |
Clostridium perfringens | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + taurine | - |
? | |
| 3.5.1.24 | taurodeoxycholic acid + H2O | - |
Clostridium perfringens | 3alpha,12alpha-dihydroxy-5beta-cholanate + taurine | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.24 | 5.6 | 5.8 | - |
Clostridium perfringens |
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