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Literature summary extracted from

  • Guengerich, F.P.
    Epoxide hydratase: properties and metabolic roles (1982), Rev. Biochem. Toxicol., 4, 5-30.
No PubMed abstract available

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.3.2.9 0.35
-
trans-beta-ethylstyrene oxide
-
Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.9 microsome
-
Cavia porcellus
-
-
3.3.2.9 microsome
-
Mus musculus
-
-
3.3.2.9 microsome
-
Homo sapiens
-
-
3.3.2.9 microsome
-
Rattus norvegicus
-
-
3.3.2.9 microsome
-
Bos taurus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.3.2.9 additional information
-
-
Mus musculus
3.3.2.9 additional information
-
-
Homo sapiens
3.3.2.9 additional information
-
enzyme aggregates in absence of amphipathic detergents Rattus norvegicus
3.3.2.9 49000
-
x * 49000, SDS-PAGE Homo sapiens
3.3.2.9 49000
-
x * 49000, SDS-PAGE Rattus norvegicus
3.3.2.9 58000
-
x * 58000, SDS-PAGE Homo sapiens
3.3.2.9 130000
-
gel filtration Mus musculus
3.3.2.9 130000
-
gel filtration Homo sapiens
3.3.2.9 600000
-
enzyme aggregate formed in absence of amphiphathic detergents, gel filtration Rattus norvegicus
3.3.2.9 800000
-
enzyme aggregate formed in absence of amphiphathic detergents, equilibrium sedimentation Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.9 additional information Cavia porcellus enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation ?
-
?
3.3.2.9 additional information Mus musculus enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation ?
-
?
3.3.2.9 additional information Homo sapiens enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation ?
-
?
3.3.2.9 additional information Rattus norvegicus enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.9 Bos taurus
-
-
-
3.3.2.9 Cavia porcellus
-
-
-
3.3.2.9 Homo sapiens
-
-
-
3.3.2.9 Mus musculus
-
-
-
3.3.2.9 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.9 liver
-
Cavia porcellus
-
3.3.2.9 liver
-
Mus musculus
-
3.3.2.9 liver
-
Homo sapiens
-
3.3.2.9 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.9 (exo)-2,3-epoxynorbornane + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 1,2-epoxybutane + H2O
-
Rattus norvegicus 2-hydroxy-n-butanol
-
?
3.3.2.9 2,3-epoxypropyl-p-methoxyphenyl ether + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 2,3-epoxypropyl-p-methoxyphenyl ether + H2O
-
Rattus norvegicus 3-(3-methoxyphenoxy)propane-1,2-diol
-
?
3.3.2.9 2-bromoethylene oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 2-chloroethylene oxide + H2O
-
Homo sapiens ?
-
?
3.3.2.9 2-chloroethylene oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 3,3,3-trichloropropylene oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 3-methylcholanthrene 11,12-oxide + H2O
-
Homo sapiens ?
-
?
3.3.2.9 3-methylcholanthrene 11,12-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 4-chlorophenyl 2,3-epoxypropyl ether + H2O
-
Cavia porcellus ?
-
?
3.3.2.9 4-chlorophenyl 2,3-epoxypropyl ether + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 4-vinylcyclohexene dioxide + H2O low activity Rattus norvegicus ?
-
?
3.3.2.9 7-methylbenzanthracene-5,6-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 benzoanthracene 5,6-oxide + H2O
-
Homo sapiens ?
-
?
3.3.2.9 benzoanthracene 5,6-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 benzopyrene 4,5-oxide + H2O
-
Cavia porcellus (-)benzopyrene 4,5-dihydrodiol
-
?
3.3.2.9 benzopyrene 4,5-oxide + H2O
-
Mus musculus (-)benzopyrene 4,5-dihydrodiol
-
?
3.3.2.9 benzopyrene 4,5-oxide + H2O
-
Homo sapiens (-)benzopyrene 4,5-dihydrodiol
-
?
3.3.2.9 benzopyrene 4,5-oxide + H2O
-
Rattus norvegicus (-)benzopyrene 4,5-dihydrodiol
-
?
3.3.2.9 benzopyrene 7,8-oxide + H2O
-
Homo sapiens ?
-
?
3.3.2.9 benzopyrene 7,8-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 benzopyrene 9,10-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 butadiene monoxide + H2O low activity Rattus norvegicus ?
-
?
3.3.2.9 cyclododecene-1,2-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 cyclohexene-1,2-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 dibenzanthracene 5,6-oxide + H2O
-
Homo sapiens ?
-
?
3.3.2.9 dibenzanthracene 5,6-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 dl-1,3-butadiene diepoxide + H2O low activity Rattus norvegicus ?
-
?
3.3.2.9 epibromhydrin + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 epichlorhydrin + H2O
-
Rattus norvegicus 3-chloro-1,2-propanediol
-
?
3.3.2.9 epifluorohydrin + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 glycidyl methacrylate + H2O low activity Rattus norvegicus ?
-
?
3.3.2.9 additional information enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation Cavia porcellus ?
-
?
3.3.2.9 additional information enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation Mus musculus ?
-
?
3.3.2.9 additional information enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation Homo sapiens ?
-
?
3.3.2.9 additional information enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation Rattus norvegicus ?
-
?
3.3.2.9 naphthalene-1,2-oxide + H2O
-
Cavia porcellus ?
-
?
3.3.2.9 naphthalene-1,2-oxide + H2O
-
Homo sapiens ?
-
?
3.3.2.9 naphthalene-1,2-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 octene 1,2-oxide + H2O
-
Homo sapiens ?
-
?
3.3.2.9 octene 1,2-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 p-nitrostyrene 7,8-oxide + H2O
-
Homo sapiens ?
-
?
3.3.2.9 p-nitrostyrene 7,8-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 phenanthrene-9,10-oxide + H2O
-
Mus musculus ?
-
?
3.3.2.9 phenanthrene-9,10-oxide + H2O
-
Homo sapiens ?
-
?
3.3.2.9 phenanthrene-9,10-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 propylene oxide + H2O low activity Rattus norvegicus ?
-
?
3.3.2.9 styrene 7,8-oxide + H2O
-
Homo sapiens styrene glycol
-
?
3.3.2.9 styrene 7,8-oxide + H2O
-
Rattus norvegicus styrene glycol
-
?
3.3.2.9 trans-ethyl styrene oxide + H2O
-
Mus musculus ?
-
?

Subunits

EC Number Subunits Comment Organism
3.3.2.9 ?
-
Cavia porcellus
3.3.2.9 ?
-
Mus musculus
3.3.2.9 ? x * 58000, SDS-PAGE Homo sapiens
3.3.2.9 ? x * 49000, SDS-PAGE Homo sapiens
3.3.2.9 ? x * 49000, SDS-PAGE Rattus norvegicus