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Literature summary extracted from
- Epoxide hydratase (1977), Mises Point Biochim. Pharmacol., 1, 127-148.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.3.2.9 | 3,3,3-trichloropropene oxide | - |
Cavia porcellus |  |
| 3.3.2.9 | 3,3,3-trichloropropene oxide | - |
Homo sapiens | |
| 3.3.2.9 | 3,3,3-trichloropropene oxide | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.3.2.9 | 0.67 | - |
styrene oxide | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.3.2.9 | microsome | - |
Cavia porcellus | - |
- |
| 3.3.2.9 | microsome | - |
Mus musculus | - |
- |
| 3.3.2.9 | microsome | - |
Homo sapiens | - |
- |
| 3.3.2.9 | microsome | - |
Rattus norvegicus | - |
- |
| 3.3.2.9 | microsome | - |
Oryctolagus cuniculus | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.3.2.9 | 49000 | - |
x * 49000, SDS-PAGE | Homo sapiens |
| 3.3.2.9 | 49000 | - |
x * 49000, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.3.2.9 | additional information | Cavia porcellus | - |
? | - |
? | |
| 3.3.2.9 | additional information | Mus musculus | - |
? | - |
? | |
| 3.3.2.9 | additional information | Rattus norvegicus | - |
? | - |
? | |
| 3.3.2.9 | additional information | Homo sapiens | the enzyme is expected to play a purely protective role with respect to epoxides metabolically produced from pharmaceutical drugs | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.3.2.9 | Cavia porcellus | - |
- |
- |
| 3.3.2.9 | Homo sapiens | - |
- |
- |
| 3.3.2.9 | Macaca mulatta | - |
- |
- |
| 3.3.2.9 | Mus musculus | - |
- |
- |
| 3.3.2.9 | Oryctolagus cuniculus | - |
- |
- |
| 3.3.2.9 | Rattus norvegicus | - |
enzyme activity is about 2.5 to 3 times higher in male than in female | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.3.2.9 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.3.2.9 | adrenal gland | - |
Cavia porcellus | - |
| 3.3.2.9 | adrenal gland | - |
Homo sapiens | - |
| 3.3.2.9 | adrenal gland | - |
Rattus norvegicus | - |
| 3.3.2.9 | bladder | - |
Rattus norvegicus | - |
| 3.3.2.9 | brain | - |
Cavia porcellus | - |
| 3.3.2.9 | brain | - |
Rattus norvegicus | - |
| 3.3.2.9 | cecum | - |
Rattus norvegicus | - |
| 3.3.2.9 | colon | - |
Rattus norvegicus | - |
| 3.3.2.9 | dermis | - |
Rattus norvegicus | - |
| 3.3.2.9 | epidermis | - |
Rattus norvegicus | - |
| 3.3.2.9 | esophagus | - |
Rattus norvegicus | - |
| 3.3.2.9 | heart | - |
Rattus norvegicus | - |
| 3.3.2.9 | kidney | - |
Mus musculus | - |
| 3.3.2.9 | kidney | - |
Homo sapiens | - |
| 3.3.2.9 | kidney | - |
Rattus norvegicus | - |
| 3.3.2.9 | kidney | - |
Oryctolagus cuniculus | - |
| 3.3.2.9 | kidney | - |
Macaca mulatta | - |
| 3.3.2.9 | liver | - |
Cavia porcellus | - |
| 3.3.2.9 | liver | - |
Mus musculus | - |
| 3.3.2.9 | liver | - |
Homo sapiens | - |
| 3.3.2.9 | liver | - |
Rattus norvegicus | - |
| 3.3.2.9 | liver | - |
Oryctolagus cuniculus | - |
| 3.3.2.9 | liver | - |
Macaca mulatta | - |
| 3.3.2.9 | lung | - |
Rattus norvegicus | - |
| 3.3.2.9 | lung | - |
Oryctolagus cuniculus | - |
| 3.3.2.9 | muscle | triceps | Rattus norvegicus | - |
| 3.3.2.9 | ovary | - |
Rattus norvegicus | - |
| 3.3.2.9 | prostate gland | - |
Rattus norvegicus | - |
| 3.3.2.9 | small intestine | - |
Cavia porcellus | - |
| 3.3.2.9 | small intestine | - |
Rattus norvegicus | - |
| 3.3.2.9 | spleen | - |
Rattus norvegicus | - |
| 3.3.2.9 | stomach | membranous and glandular | Rattus norvegicus | - |
| 3.3.2.9 | subcutis | - |
Rattus norvegicus | - |
| 3.3.2.9 | submandibular gland | - |
Rattus norvegicus | - |
| 3.3.2.9 | testis | - |
Mus musculus | - |
| 3.3.2.9 | testis | - |
Homo sapiens | - |
| 3.3.2.9 | testis | - |
Rattus norvegicus | - |
| 3.3.2.9 | testis | - |
Oryctolagus cuniculus | - |
| 3.3.2.9 | testis | - |
Macaca mulatta | - |
| 3.3.2.9 | thymus | - |
Rattus norvegicus | - |
| 3.3.2.9 | tongue | - |
Rattus norvegicus | - |
| 3.3.2.9 | trachea | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.3.2.9 | 0.516 | - |
- |
Rattus norvegicus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.3.2.9 | 0°C, 50 mM sodium phosphate buffer, pH 7.0, 2 months, stable | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.3.2.9 | additional information | - |
Cavia porcellus | ? | - |
? | |
| 3.3.2.9 | additional information | - |
Mus musculus | ? | - |
? | |
| 3.3.2.9 | additional information | - |
Rattus norvegicus | ? | - |
? | |
| 3.3.2.9 | additional information | the enzyme is expected to play a purely protective role with respect to epoxides metabolically produced from pharmaceutical drugs | Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.3.2.9 | ? | - |
Cavia porcellus |
| 3.3.2.9 | ? | - |
Mus musculus |
| 3.3.2.9 | ? | x * 49000, SDS-PAGE | Homo sapiens |
| 3.3.2.9 | ? | x * 49000, SDS-PAGE | Rattus norvegicus |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.3.2.9 | 25 | - |
pH 7.0, 5 h, stable | Rattus norvegicus |
| 3.3.2.9 | 37 | - |
- |
Mus musculus |
| 3.3.2.9 | 37 | - |
- |
Homo sapiens |
| 3.3.2.9 | 37 | - |
pH 7.0, 24 h, less than 10% inactivation | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.3.2.9 | 8.9 | - |
hydration of styrene oxide, Tris buffer | Rattus norvegicus |
| 3.3.2.9 | 9 | - |
- |
Mus musculus |
| 3.3.2.9 | 9 | - |
hydration of styrene oxide in sodium phosphate buffer | Rattus norvegicus |
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