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Literature summary extracted from

  • Seidegard, J.; DePierre, J.W.
    Microsomal epoxide hydrolase. Properties, regulation and function (1983), Biochim. Biophys. Acta, 695, 251-270.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.3.2.9 1(2-naphthyl)-2-phenylethanedione stimulates Rattus norvegicus
3.3.2.9 benzil stimulates Rattus norvegicus
3.3.2.9 chalcone epoxide stimulates Rattus norvegicus
3.3.2.9 clotrimazole stimulates Rattus norvegicus
3.3.2.9 ellipticine stimulates Rattus norvegicus
3.3.2.9 flavone stimulates Rattus norvegicus
3.3.2.9 Harmane stimulates Rattus norvegicus
3.3.2.9 Isoquinoline stimulates Rattus norvegicus
3.3.2.9 Metyrapone
-
Oryctolagus cuniculus
3.3.2.9 Metyrapone stimulates Rattus norvegicus
3.3.2.9 nitroanisil stimulates Rattus norvegicus
3.3.2.9 norharmane stimulates Rattus norvegicus
3.3.2.9 p-anisil stimulates Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.9 microsome
-
Rattus norvegicus
-
-
3.3.2.9 microsome
-
Oryctolagus cuniculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.9 additional information Rattus norvegicus enzyme is involved in the metabolism of steroids, the microsomal enzyme plays a central role in both the inactivation of primary mutagenic and carcinogenic metabolites of polycyclic aromatic hydrocarbons, and in activating these metabolites to even more toxic or mutagenic secondary products, enzyme production is induced by 3-methylcholanthrene, phenobarbital, trans-stilbene oxide, 2(3)-tert-butyl-4-hydroxyanisol or 2-acetylaminofluorene ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.9 Oryctolagus cuniculus
-
-
-
3.3.2.9 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.9 liver
-
Rattus norvegicus
-
3.3.2.9 liver
-
Oryctolagus cuniculus
-

Storage Stability

EC Number Storage Stability Organism
3.3.2.9 0°C, 50 mM sodium phosphate buffer, pH 7.0, 2 months, stable Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.9 1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,41,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,41,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O
-
Oryctolagus cuniculus ?
-
?
3.3.2.9 androstene oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 benzene oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 benzoanthracene 5,6-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 benzopyrene 11,12-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 benzopyrene 4,5-oxide + H2O
-
Rattus norvegicus (-)benzopyrene 4,5-dihydrodiol
-
?
3.3.2.9 benzopyrene 4,5-oxide + H2O
-
Oryctolagus cuniculus (-)benzopyrene 4,5-dihydrodiol
-
?
3.3.2.9 benzopyrene 7,8-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 benzopyrene 9,10-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 cis-stilbene oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 cis-stilbene oxide + H2O
-
Oryctolagus cuniculus ?
-
?
3.3.2.9 dibenzoanthracene + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 estroxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 additional information enzyme is involved in the metabolism of steroids, the microsomal enzyme plays a central role in both the inactivation of primary mutagenic and carcinogenic metabolites of polycyclic aromatic hydrocarbons, and in activating these metabolites to even more toxic or mutagenic secondary products, enzyme production is induced by 3-methylcholanthrene, phenobarbital, trans-stilbene oxide, 2(3)-tert-butyl-4-hydroxyanisol or 2-acetylaminofluorene Rattus norvegicus ?
-
?
3.3.2.9 naphthalene-1,2-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 octene 1,2-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 phenanthrene-9,10-oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 styrene 7,8-oxide + H2O
-
Rattus norvegicus styrene glycol
-
?
3.3.2.9 trans-ethyl styrene oxide + H2O
-
Rattus norvegicus ?
-
?
3.3.2.9 trans-ethyl styrene oxide + H2O
-
Oryctolagus cuniculus ?
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.3.2.9 8.9 9.4 hydration of styrene 7,8-oxide Rattus norvegicus