Literature summary extracted from

Tavassoli, M.; Tavassoli, M.H.; Shall, S.
Isolation and purification of poly(ADP-ribose) glycohydrolase from pig thymus (1983), Eur. J. Biochem., 135, 449-455.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.2.1.143	2-mercaptoethanol	10 mM, stimulates by 70%	Sus scrofa
3.2.1.143	dithiothreitol	10 mM, stimulates by 70%	Sus scrofa

EC Number	Inhibitors	Comment	Organism
3.2.1.143	1-Naphthylamine	1 mM, 45% inhibition	Sus scrofa
3.2.1.143	2-naphthalene sulfonic acid	5 mM, 26% inhibition	Sus scrofa
3.2.1.143	2-Naphthylamine	1 mM, 50% inhibition	Sus scrofa
3.2.1.143	4-amino-3-hydroxynaphthalene 1-sulfonic acid	5 m, 79% inhibition	Sus scrofa
3.2.1.143	8-bromoadenosine 3',5'-monophosphate	5 mM, 13% inhibition	Sus scrofa
3.2.1.143	8-methylaminoadenosine 3',5'-monophosphate	5 mM, 14% inhibition	Sus scrofa
3.2.1.143	adenine(5'-9)ribofuranoside	5 mM, 24% inhibition	Sus scrofa
3.2.1.143	adenosine 5'-carboxylic acid	5 mM, 26% inhibition	Sus scrofa
3.2.1.143	ADP-ribose	-	Sus scrofa
3.2.1.143	CaCl2	5 mM 86% inhibition	Sus scrofa
3.2.1.143	cAMP	-	Sus scrofa
3.2.1.143	cyclic dAMP	5 mM, 34% inhibition	Sus scrofa
3.2.1.143	DNA	single-stranded DNA, no inhibition by double-stranded DNA	Sus scrofa
3.2.1.143	histone	histone H1, H2A, H2B and H3	Sus scrofa
3.2.1.143	MgCl2	10 mM, 18% inhibition	Sus scrofa
3.2.1.143	N1-naphthylethanenediamine	5 mM, 70% inhibition	Sus scrofa
3.2.1.143	NaCl	400 mM, 75% inhibition	Sus scrofa
3.2.1.143	naphthylamine	-	Sus scrofa
3.2.1.143	Poly(A)	-	Sus scrofa
3.2.1.143	poly(I)	-	Sus scrofa
3.2.1.143	poly(L-Arg)	-	Sus scrofa
3.2.1.143	poly(L-Lys)	-	Sus scrofa
3.2.1.143	poly(L-Orn)	-	Sus scrofa
3.2.1.143	polyvinylsulfate	-	Sus scrofa
3.2.1.143	protamine	-	Sus scrofa

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
3.2.1.143	0.0018	-	Poly(ADP-ribose)	as monomer units	Sus scrofa

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
3.2.1.143	59000	-	gel filtration	Sus scrofa

EC Number	Organism	UniProt	Comment	Textmining
3.2.1.143	Sus scrofa	-	-	-

EC Number	Purification (Comment)	Organism
3.2.1.143	-	Sus scrofa

EC Number	Source Tissue	Comment	Organism	Textmining
3.2.1.143	thymus	-	Sus scrofa	-

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
3.2.1.143	13.8	-	-	Sus scrofa

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.2.1.143	poly(ADP-ribose)n + H2O	-	Sus scrofa	ADP-ribose	-	?

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
3.2.1.143	7.5	-	-	Sus scrofa

EC Number	pH Minimum	pH Maximum	Comment	Organism
3.2.1.143	6	9	the enzyme is active between pH 6 and 9	Sus scrofa

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
3.2.1.143	1	-	2-Naphthylamine	-	Sus scrofa