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Literature summary extracted from

  • Maruta, H.; Inageda, K.; Aoki, T.; Nishina, H.; Tanuma, S.I.
    Characterization of two forms of poly(ADP-ribose) glycohydrolase in guniea pig liver (1991), Biochemistry, 30, 5907-5912.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.143 ADP-ribose inhibits poly(ADP-ribose) glycohydrolase II more strongly than poly(ADP-ribose) glycohydrolase I Cavia porcellus
3.2.1.143 cAMP inhibits poly(ADP-ribose) glycohydrolase II more strongly than poly(ADP-ribose) glycohydrolase I Cavia porcellus
3.2.1.143 KCl 100 mM, 50% inhibition, poly(ADP-ribose) glycohydrolase II Cavia porcellus
3.2.1.143 NaCl 50-100 mM, poly(ADP-ribose) glycohydrolase II Cavia porcellus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.143 0.00058
-
 (ADP-ribose)n average chain length n = 27, poly(ADP-ribose) glycohydrolase I Cavia porcellus
3.2.1.143 0.0011
-
 (ADP-ribose)n average chain length n = 21, poly(ADP-ribose) glycohydrolase I Cavia porcellus
3.2.1.143 0.002
-
 (ADP-ribose)n average chain length n = 15, poly(ADP-ribose) glycohydrolase I Cavia porcellus
3.2.1.143 0.0031
-
 (ADP-ribose)n average chain length n = 27, poly(ADP-ribose) glycohydrolase II Cavia porcellus
3.2.1.143 0.004
-
 (ADP-ribose)n average chain length n = 21, poly(ADP-ribose) glycohydrolase II Cavia porcellus
3.2.1.143 0.0045
-
 (ADP-ribose)n average chain length n = 6.7, poly(ADP-ribose) glycohydrolase I Cavia porcellus
3.2.1.143 0.0048
-
 (ADP-ribose)n average chain length n = 15, poly(ADP-ribose) glycohydrolase II Cavia porcellus
3.2.1.143 0.0066
-
 (ADP-ribose)n average chain length n = 6.7, poly(ADP-ribose) glycohydrolase II Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.143 cytoplasm poly(ADP-ribose) glycohydrolase II Cavia porcellus 5737
-
3.2.1.143 nucleus poly(ADP-ribose) glycohydrolase I Cavia porcellus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.2.1.143 KCl 50-100 mM, stimulates poly(ADP-ribose) glycohydrolase I Cavia porcellus
3.2.1.143 NaCl 50-100 mM, stimulates poly(ADP-ribose) glycohydrolase I Cavia porcellus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.1.143 57000
-
 poly(ADP-ribose) glycohydrolase II, gel filtration Cavia porcellus
3.2.1.143 59500
-
 1 * 59500, poly(ADP-ribose) glycohydrolase II, SDS-PAGE Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.143 Cavia porcellus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.1.143 cytoplasmic enzyme Cavia porcellus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.143 liver
-
 Cavia porcellus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.2.1.143 13.4
-
 poly(ADP-ribose) glycohydrolase II Cavia porcellus

Storage Stability

EC Number Storage Stability Organism
3.2.1.143 -20°C, stable for at least 6 months Cavia porcellus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.143 poly(ADP-ribose)n + H2O
-
 Cavia porcellus ADP-ribose
-
 ?

Subunits

EC Number Subunits Comment Organism
3.2.1.143 monomer 1 * 59500, poly(ADP-ribose) glycohydrolase II, SDS-PAGE Cavia porcellus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.143 7
-
 poly(ADP-ribose) glycohydrolase I Cavia porcellus
3.2.1.143 7.4
-
 poly(ADP-ribose) glycohydrolase II Cavia porcellus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.2.1.143 6 9 optimal stability Cavia porcellus