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Literature summary extracted from

  • Pan, F.; Yu, T.C.; Duh, G.M.; Lee, H.H.
    Specificity and kinetic properties of the cysteinyl-tRNA synthetase from rat liver (1976), J. Chin. Biochem. Soc., 5, 45-56.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.16 2'-deoxy-ATP
-
Rattus norvegicus
6.1.1.16 ADP noncompetitive Rattus norvegicus
6.1.1.16 alpha,beta-CH2-ATP competitive Rattus norvegicus
6.1.1.16 AMP noncompetitive Rattus norvegicus
6.1.1.16 ATP at high concentrations Rattus norvegicus
6.1.1.16 Ba2+ 10 mM, 43% inhibition in presence of 10 mM Mg2+, no activation in absence of Mg2+ Rattus norvegicus
6.1.1.16 Ca2+ 10 mM, 28% inhibition in presence of 10 mM Mg2+, no activation in absence of Mg2+ Rattus norvegicus
6.1.1.16 Co2+ 10 mM, complete inhibition in presence of 10 mM Mg2+, no activation in absence of Mg2+ Rattus norvegicus
6.1.1.16 Cu2+ 10 mM, complete inhibition in presence of 10 mM Mg2+, no activation in absence of Mg2+ Rattus norvegicus
6.1.1.16 cysteamine competitive Rattus norvegicus
6.1.1.16 cysteine at high concentrations Rattus norvegicus
6.1.1.16 D-cysteine weak, non-competitive Rattus norvegicus
6.1.1.16 diphosphate at high concentrations Rattus norvegicus
6.1.1.16 GTP noncompetitive Rattus norvegicus
6.1.1.16 Hg2+ 10 mM, complete inhibition in presence of 10 mM Mg2+, no activation in absence of Mg2+ Rattus norvegicus
6.1.1.16 iodoacetamide partially Rattus norvegicus
6.1.1.16 L-homocysteine
-
Rattus norvegicus
6.1.1.16 S-methyl-L-cysteine competitive Rattus norvegicus
6.1.1.16 Sodium tripolyphosphate
-
Rattus norvegicus
6.1.1.16 Zn2+ 10 mM, complete inhibition in presence of 10 mM Mg2+, no activation in absence of Mg2+ Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.1.1.16 0.03
-
Cys
-
Rattus norvegicus
6.1.1.16 0.16
-
diphosphate
-
Rattus norvegicus
6.1.1.16 1.8
-
ATP
-
Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.1.1.16 Mg2+ optimal concentration: 10 mM Rattus norvegicus
6.1.1.16 Mg2+ inhibition above 15 mM Rattus norvegicus
6.1.1.16 Mg2+ required for ATP-diphosphate exchange Rattus norvegicus
6.1.1.16 Mg2+ Km: 3.6 mM Rattus norvegicus
6.1.1.16 Mn2+ can partially replace Mg2+ in activation of cysteine, optimal concentration is 5 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.16 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.1.1.16
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.1.1.16 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.16 ATP + L-cysteine + tRNACys
-
Rattus norvegicus AMP + diphosphate + L-cysteinyl-tRNACys
-
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pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.1.1.16 7.5
-
-
Rattus norvegicus