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Literature summary extracted from

  • Lau, E.P.; Fall, R.R.
    3-Methylcrotonyl-CoA carboxylase from bovine kidney. EC 6.4.1.4. 3-Methylcrotonyl-CoA: carbon dioxide ligase (ADP-forming) (1981), Methods Enzymol., 71, 800-804.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.4.1.4 0.078
-
 3-methylcrotonoyl-CoA kidney enzyme Bos taurus
6.4.1.4 0.082
-
 ATP kidney enzyme Bos taurus
6.4.1.4 1.8
-
 HCO3- kidney enzyme Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.4.1.4 mitochondrial inner membrane
-
 Bos taurus 5743
-
6.4.1.4 mitochondrion
-
 Bos taurus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.4.1.4 K+ activated 4 to 5fold by K+ or NH4+, 50-100 mM, kidney enzyme Bos taurus
6.4.1.4 NH4+ activated 4 to 5fold by K+ or NH4+, 50-100 mM, kidney enzyme Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.4.1.4 835000
-
 PAGE, gel filtration Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.4 Bos taurus
-
-
-
6.4.1.4 Homo sapiens
-
-
-
6.4.1.4 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.4.1.4 kidney enzyme Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.4.1.4 adrenal gland
-
 Bos taurus
-
6.4.1.4 kidney
-
 Rattus norvegicus
-
6.4.1.4 kidney
-
 Bos taurus
-
6.4.1.4 liver
-
 Rattus norvegicus
-
6.4.1.4 liver
-
 Bos taurus
-
6.4.1.4 lung
-
 Bos taurus
-
6.4.1.4 placenta
-
 Homo sapiens
-
6.4.1.4 skeletal muscle
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.4.1.4 3.84
-
 kidney enzyme Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.4 ATP + 3-methylcrotonoyl-CoA + HCO3-
-
 Homo sapiens ADP + phosphate + 3-methylglutaconyl-CoA
-
 ?
6.4.1.4 ATP + 3-methylcrotonoyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + 3-methylglutaconyl-CoA
-
 ?
6.4.1.4 ATP + 3-methylcrotonoyl-CoA + HCO3-
-
 Bos taurus ADP + phosphate + 3-methylglutaconyl-CoA
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.4 biotin enzyme contains biotin Homo sapiens
6.4.1.4 biotin enzyme contains biotin Rattus norvegicus
6.4.1.4 biotin enzyme contains biotin Bos taurus
6.4.1.4 biotin contains 1 mol biotin per 157000 MW AB protomeric structure Bos taurus