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Literature summary extracted from

  • Mori, M.; Tatibana, M.
    Glutamine-dependent carbamoyl phosphate synthetase: polyamines inhibit the activity and modify the activating effect of 5-phosphoribosyl 1-pyrophosphate (1975), Biochem. Biophys. Res. Commun., 67, 287-293.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.5 polyamines inhibition is partially reversed by increasing the concentration of Mg2+ or MgATP2-, or by adding low concentrations of 5-phosphoribosyl 1-diphosphate Mammalia
6.3.5.5 polyamines
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.5 Mammalia
-
-
-
6.3.5.5 Mus musculus
-
-
-
6.3.5.5 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.5.5 liver
-
 Rattus norvegicus
-
6.3.5.5 spleen
-
 Mus musculus
-
6.3.5.5 spleen
-
 Rattus norvegicus
-
6.3.5.5 Yoshida AH-130 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.5 2 ATP + L-Gln + HCO3-
-
 Mammalia 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?
6.3.5.5 2 ATP + L-Gln + HCO3-
-
 Mus musculus 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?
6.3.5.5 2 ATP + L-Gln + HCO3-
-
 Rattus norvegicus 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?