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Literature summary extracted from

  • Coleman, P.F.; Suttle, D.P.; Stark, G.R.
    Purification of a multifunctional protein bearing carbamyl-phosphate synthase, aspartate transcarbamylase, and dihydroorotase enzyme activities from mutant hamster cells (1978), Methods Enzymol., 51, 121-134.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.3.2 carbamoylphosphate + L-aspartate Mesocricetus auratus
-
 phosphate + N-carbamoyl-L-aspartate
-
 ?
3.5.2.3 N-carbamoyl-L-aspartate Cricetinae
-
 L-dihydroorotate + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.2 Mesocricetus auratus
-
-
-
3.5.2.3 Cricetinae
-
-
-
6.3.5.5 Mesocricetus auratus
-
 mutant
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.3.2
-
 Mesocricetus auratus
3.5.2.3
-
 Cricetinae
6.3.5.5 multifunctional protein bearing carbamoyl-phosphate synthase, aspartate transcarbamoylase, and dihydroorotase activities Mesocricetus auratus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.3.2 cell culture
-
 Mesocricetus auratus
-
3.5.2.3 kidney
-
 Cricetinae
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.2.3 2.66
-
-
 Cricetinae
6.3.5.5 additional information
-
-
 Mesocricetus auratus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.2 carbamoyl phosphate + L-aspartate
-
 Mesocricetus auratus phosphate + N-carbamoyl-L-aspartate
-
 ?
2.1.3.2 carbamoylphosphate + L-aspartate
-
 Mesocricetus auratus phosphate + N-carbamoyl-L-aspartate
-
 ?
3.5.2.3 L-carbamoylaspartate
-
 Cricetinae L-dihydroorotate + H2O
-
 r
3.5.2.3 N-carbamoyl-L-aspartate
-
 Cricetinae L-dihydroorotate + H2O
-
 r
6.3.5.5 2 ATP + L-Gln + HCO3-
-
 Mesocricetus auratus 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.3.2 More
-
 Mesocricetus auratus