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Literature summary extracted from

  • Meek, T.D.; Karsten, W.E.; DeBrosse, C.W.
    Carbamoyl-phosphate synthetase II of the mammalian CAD protein: kinetic mechanism and elucidation of reaction intermediates by positional isotope exchange (1987), Biochemistry, 26, 2584-2593.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.5 Carbamoyl phosphate
-
 Mesocricetus auratus
6.3.5.5 L-Glu
-
 Mesocricetus auratus
6.3.5.5 MgATP2- product inhibition Mesocricetus auratus
6.3.5.5 phosphate
-
 Mesocricetus auratus

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.5 Mesocricetus auratus
-
 Syrian hamster
-

Reaction

EC Number Reaction Comment Organism Reaction ID
6.3.5.5 2 ATP + L-glutamine + hydrogencarbonate + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate partially random sequential mechanism in which the ordered addition of MgATP2- , HCO3-, and Gln is followed by the ordered release of Glu and phosphate. The formation of carbamate from MgATP2-, HCO3-, and Gln proceeds via a stepwise, not concerted mechanism, involving at least one kinetically competent covalent intermediate, such as carboxyphosphate Mesocricetus auratus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.5.5 BHK 165-23 cell SV40-transformed Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.5 2 ATP + L-Gln + HCO3-
-
 Mesocricetus auratus 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?