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Literature summary extracted from

  • Kidder, G.W.; Nolan, L.L.
    Adenine aminohydrolase: occurrence and possible significance in trypanosomid flagellates (1979), Proc. Natl. Acad. Sci. USA, 76, 3670-3672.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.2 coformycin
-
 Crithidia fasciculata
3.5.4.2 coformycin
-
 Leishmania braziliensis
3.5.4.2 coformycin
-
 Leishmania donovani
3.5.4.2 coformycin
-
 Leishmania mexicana
3.5.4.2 coformycin
-
 Leishmania tarentolae
3.5.4.2 Deoxycoformycin
-
 Crithidia fasciculata
3.5.4.2 Deoxycoformycin
-
 Leishmania braziliensis
3.5.4.2 Deoxycoformycin
-
 Leishmania donovani
3.5.4.2 Deoxycoformycin
-
 Leishmania mexicana
3.5.4.2 Deoxycoformycin
-
 Leishmania tarentolae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.2 0.7 0.8 adenine
-
 Leishmania braziliensis
3.5.4.2 0.8 1 adenine
-
 Crithidia fasciculata
3.5.4.2 1.1 1.4 adenine
-
 Leishmania tarentolae
3.5.4.2 1.7 2 adenine
-
 Leishmania mexicana
3.5.4.2 2 2.2 adenine
-
 Leishmania donovani

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.2 adenine + H2O Crithidia fasciculata
-
 ?
-
 ?
3.5.4.2 adenine + H2O Leishmania donovani
-
 ?
-
 ?
3.5.4.2 adenine + H2O Leishmania tarentolae
-
 ?
-
 ?
3.5.4.2 adenine + H2O Leishmania mexicana
-
 ?
-
 ?
3.5.4.2 adenine + H2O Leishmania braziliensis
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.2 Crithidia fasciculata
-
-
-
3.5.4.2 Leishmania braziliensis
-
-
-
3.5.4.2 Leishmania donovani
-
-
-
3.5.4.2 Leishmania mexicana
-
-
-
3.5.4.2 Leishmania tarentolae
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.2 0.012
-
-
 Leishmania braziliensis
3.5.4.2 0.22
-
-
 Leishmania mexicana
3.5.4.2 0.58
-
-
 Leishmania tarentolae
3.5.4.2 0.64
-
-
 Leishmania donovani
3.5.4.2 0.71
-
-
 Crithidia fasciculata

Storage Stability

EC Number Storage Stability Organism
3.5.4.2 4°C, 10 mM phoshate buffer, pH7.5, 20 mM 2-mercaptoethanol, 1-2 weeks, minimal losses Crithidia fasciculata
3.5.4.2 4°C, 10 mM phoshate buffer, pH7.5, 20 mM 2-mercaptoethanol, 1-2 weeks, minimal losses Leishmania tarentolae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.2 adenine + H2O
-
 Crithidia fasciculata hypoxanthine + NH3
-
 ?
3.5.4.2 adenine + H2O
-
 Leishmania donovani hypoxanthine + NH3
-
 ?
3.5.4.2 adenine + H2O
-
 Leishmania tarentolae hypoxanthine + NH3
-
 ?
3.5.4.2 adenine + H2O
-
 Leishmania mexicana hypoxanthine + NH3
-
 ?
3.5.4.2 adenine + H2O
-
 Leishmania braziliensis hypoxanthine + NH3
-
 ?
3.5.4.2 adenine + H2O
-
 Crithidia fasciculata ?
-
 ?
3.5.4.2 adenine + H2O
-
 Leishmania donovani ?
-
 ?
3.5.4.2 adenine + H2O
-
 Leishmania tarentolae ?
-
 ?
3.5.4.2 adenine + H2O
-
 Leishmania mexicana ?
-
 ?
3.5.4.2 adenine + H2O
-
 Leishmania braziliensis ?
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.5.4.2 50
-
 95% loss of activity after 1 min Leishmania donovani
3.5.4.2 50
-
 95% loss of activity after 1 min Leishmania tarentolae
3.5.4.2 50
-
 95% loss of activity after 1 min Leishmania mexicana
3.5.4.2 50
-
 95% loss of activity after 1 min Leishmania braziliensis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.2 8
-
-
 Crithidia fasciculata
3.5.4.2 8
-
-
 Leishmania donovani
3.5.4.2 8
-
-
 Leishmania tarentolae
3.5.4.2 8
-
-
 Leishmania mexicana
3.5.4.2 8
-
-
 Leishmania braziliensis