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Literature summary extracted from
- Acetylspermidine deacetylase (rat liver) (1983), Methods Enzymol., 94, 329-331.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.48 | dithiothreitol | 64% activation at 1 mM | Rattus sp. |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.48 | 1,4-diaminobutane | competitive inhibition, Ki: 0.25 mM; putrescine | Rattus sp. | |
| 3.5.1.48 | spermidine | competitive inhibition, Ki: 0.055 mM | Rattus sp. | |
| 3.5.1.48 | spermine | competitive inhibition, Ki: 0.036 mM | Rattus sp. | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.1.48 | 0.003 | - |
N1-acetylspermidine | - |
Rattus sp. | |
| 3.5.1.48 | 0.016 | - |
N1-acetylspermine | - |
Rattus sp. | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.5.1.48 | cytosol | - |
Rattus sp. | 5829 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.48 | Rattus sp. | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.5.1.48 | 29fold, chromatography techniques | Rattus sp. |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.1.48 | liver | - |
Rattus sp. | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.48 | 0.54 | - |
- |
Rattus sp. |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.5.1.48 | -20°C, presence of glycerol and thioglycerol, fully active up to 6 months | Rattus sp. |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.48 | N1-acetylspermidine + H2O | - |
Rattus sp. | acetate + spermidine | - |
? | |
| 3.5.1.48 | N1-acetylspermine + H2O | - |
Rattus sp. | spermine + acetate | - |
? | |
| 3.5.1.48 | N8-acetylspermidine + H2O | - |
Rattus sp. | acetate + spermidine | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.48 | 10.4 | - |
- |
Rattus sp. |
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