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Literature summary extracted from

  • Nilsson, L.; Kagedal, B.
    Lipoamidase and biotinidase activities in the rat: Tissue distribution and intracellular localization (1994), Eur. J. Clin. Chem. Clin. Biochem., 32, 501-509.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.12 CuCl2
-
 Homo sapiens
3.5.1.12 CuCl2
-
 Rattus rattus
3.5.1.12 diisopropylfluorophosphate
-
 Rattus rattus
3.5.1.12 Hg2+
-
 Homo sapiens
3.5.1.12 Hg2+
-
 Rattus rattus
3.5.1.12 p-hydroxymercuribenzoate
-
 Homo sapiens
3.5.1.12 p-hydroxymercuribenzoate
-
 Rattus rattus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.12 0.69
-
 lipoyl-4-aminobenzoic acid + pH 9.5 Rattus rattus
3.5.1.12 1.3
-
 lipoyllysine
-
 Rattus rattus
3.5.1.12 1.3
-
 lipoyl-4-aminobenzoic acid + pH 6.0 Rattus rattus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.12 microsome
-
 Cavia porcellus
-
-
3.5.1.12 microsome
-
 Rattus rattus
-
-
3.5.1.12 mitochondrion
-
 Homo sapiens 5739
-
3.5.1.12 mitochondrion
-
 Rattus rattus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.12 biotin amide + H2O Cavia porcellus
-
 ?
-
 ?
3.5.1.12 biotin amide + H2O Homo sapiens
-
 ?
-
 ?
3.5.1.12 biotin amide + H2O Rattus rattus
-
 ?
-
 ?
3.5.1.12 epsilon-N-(D,L-lipoyl)-L-lysine + H2O Homo sapiens
-
 ?
-
 ?
3.5.1.12 epsilon-N-(D,L-lipoyl)-L-lysine + H2O Rattus rattus
-
 ?
-
 ?
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O Cavia porcellus
-
 ?
-
 ?
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O Homo sapiens
-
 ?
-
 ?
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O Rattus rattus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.12 Cavia porcellus
-
 guinea pig
-
3.5.1.12 Homo sapiens
-
 human
-
3.5.1.12 Rattus rattus
-
 rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.12
-
 Cavia porcellus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.12 blood serum, plasma, leukocytes Homo sapiens
-
3.5.1.12 blood serum, plasma, leukocytes Rattus rattus
-
3.5.1.12 brain
-
 Cavia porcellus
-
3.5.1.12 brain
-
 Homo sapiens
-
3.5.1.12 brain
-
 Rattus rattus
-
3.5.1.12 kidney
-
 Homo sapiens
-
3.5.1.12 kidney
-
 Rattus rattus
-
3.5.1.12 large intestine
-
 Rattus rattus
-
3.5.1.12 liver
-
 Cavia porcellus
-
3.5.1.12 liver
-
 Homo sapiens
-
3.5.1.12 liver
-
 Rattus rattus
-
3.5.1.12 lung
-
 Rattus rattus
-
3.5.1.12 pancreas
-
 Rattus rattus
-
3.5.1.12 small intestine
-
 Homo sapiens
-
3.5.1.12 small intestine
-
 Rattus rattus
-
3.5.1.12 spleen
-
 Rattus rattus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.12 (N-D,L-lipoyl-p-aminobenzoic acid) + H2O
-
 Homo sapiens ?
-
 ?
3.5.1.12 (N-D,L-lipoyl-p-aminobenzoic acid) + H2O
-
 Rattus rattus ?
-
 ?
3.5.1.12 biotin amide + H2O
-
 Cavia porcellus ?
-
 ?
3.5.1.12 biotin amide + H2O
-
 Homo sapiens ?
-
 ?
3.5.1.12 biotin amide + H2O
-
 Rattus rattus ?
-
 ?
3.5.1.12 epsilon-N-(D,L-lipoyl)-L-lysine + H2O
-
 Homo sapiens ?
-
 ?
3.5.1.12 epsilon-N-(D,L-lipoyl)-L-lysine + H2O
-
 Rattus rattus ?
-
 ?
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O
-
 Cavia porcellus biotin + L-lysine
-
 ir
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O
-
 Homo sapiens biotin + L-lysine
-
 ir
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O
-
 Rattus rattus biotin + L-lysine
-
 ir
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O
-
 Cavia porcellus ?
-
 ?
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O
-
 Homo sapiens ?
-
 ?
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O
-
 Rattus rattus ?
-
 ?
3.5.1.12 lipoyl-4-aminobenzoic acid + H2O
-
 Rattus rattus ?
-
 ?
3.5.1.12 lipoyllysine + H2O
-
 Rattus rattus ?
-
 ?
3.5.1.12 p-(N-biotinylamino)benzoic acid + H2O
-
 Homo sapiens biotin + p-aminobenzoic acid
-
 ir
3.5.1.12 p-(N-biotinylamino)benzoic acid + H2O
-
 Rattus rattus biotin + p-aminobenzoic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.12 lipoamidase biotinidase and lipoamidase can be separated from each other Cavia porcellus
3.5.1.12 lipoamidase not yet given an EC number, seems to be identical with biotinidase Rattus rattus
3.5.1.12 lipolysine hydrolase not yet given an EC number, seems to be identical with biotinidase Rattus rattus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.5.1.12 60 70
-
 Homo sapiens
3.5.1.12 60 70
-
 Rattus rattus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.12 5.5
-
 lipoyllysine as substrate Rattus rattus
3.5.1.12 6
-
 enzyme from plasma, liver enzyme has 2 pH optima at pH 6.0 and pH 9.5 with lipoyl-p-aminobenzoic acid as substrate Rattus rattus
3.5.1.12 9.5
-
 liver enzyme has 2 pH optima at pH 6.0 and pH 9.5 with lipoyl-p-aminobenzoic acid as substrate Rattus rattus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.5.1.12 6 9.5
-
 Rattus rattus