Any feedback?
Literature summary extracted from
- Hydrolysis of galactosylsphingosine and lactosylsphingosine by beta-galactosidases in human brain and cultured fibroblasts (1987), Biochim. Biophys. Acta, 920, 259-265.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.2.1.46 | Activator protein | purified from normal spleen | Homo sapiens | |
| 3.2.1.46 | cholate | - |
Homo sapiens |  |
| 3.2.1.46 | phosphatidylcholine | from 0.02 mg to 0.1 mg | Homo sapiens | |
| 3.2.1.46 | phosphatidylinositol | from 0.02 mg to 0.05 mg | Homo sapiens | |
| 3.2.1.46 | phosphatidylserine | at 0.02 mg | Homo sapiens | |
| 3.2.1.46 | taurocholate | - |
Homo sapiens | |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.2.1.46 | medicine | enzyme deficiency in globoid cell leucodystrophy or Krabbe disease | Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.2.1.46 | 0.11 | - |
galactosylsphingosine | without taurocholate | Homo sapiens | |
| 3.2.1.46 | 0.67 | - |
galactosylsphingosine | with taurocholate | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.46 | D-galactosyl-N-acylsphingosine + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.2.1.46 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.2.1.46 | brain | - |
Homo sapiens | - |
| 3.2.1.46 | skin fibroblast | in culture | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.46 | D-galactosyl-N-acylsphingosine + H2O | - |
Homo sapiens | D-galactose + N-acylsphingosine | - |
? | |
| 3.2.1.46 | D-galactosyl-N-acylsphingosine + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.2.1.46 | galactocerebroside + H2O | - |
Homo sapiens | D-galactose + N-acylceramide | - |
? | |
| 3.2.1.46 | lactosylsphingosine + H2O | - |
Homo sapiens | lactose + sphingosine | - |
? | |
| 3.2.1.46 | psychosine + H2O | - |
Homo sapiens | D-galactose + sphingosine | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.2.1.46 | 3.75 | - |
without taurocholate | Homo sapiens |
| 3.2.1.46 | 5.4 | - |
with taurocholate | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
