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Literature summary extracted from

  • Kalz-Fuller, B.; Bieberich, E.; Bause, E.
    Cloning and expression of glucosidase I from human hippocampus (1995), Eur. J. Biochem., 231, 344-351.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.1.106 cDNA, overexpression in COS 1 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.106 1-deoxynojirimycin strong inhibition Homo sapiens
3.2.1.106 1-deoxynojirimycin strong inhibition Sus scrofa
3.2.1.106 additional information no inhibition by 1-deoxymannojirimycin Homo sapiens
3.2.1.106 additional information no inhibition by 1-deoxymannojirimycin Sus scrofa
3.2.1.106 N,N-dimethyl-1-deoxynojirimycin specific inhibitor; strong inhibition Homo sapiens
3.2.1.106 N,N-dimethyl-1-deoxynojirimycin specific inhibitor; strong inhibition Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.106 endoplasmic reticulum endoplasmic reticulum-resident glycoprotein Homo sapiens 5783
-
3.2.1.106 endoplasmic reticulum endoplasmic reticulum-resident glycoprotein Sus scrofa 5783
-
3.2.1.106 endoplasmic reticulum catalytic site/active centre located at lumenal side of endoplasmic reticulum Homo sapiens 5783
-
3.2.1.106 endoplasmic reticulum catalytic site/active centre located at lumenal side of endoplasmic reticulum Sus scrofa 5783
-
3.2.1.106 membrane membrane-bound Homo sapiens 16020
-
3.2.1.106 membrane membrane-bound Sus scrofa 16020
-
3.2.1.106 membrane type-II transmembrane protein Homo sapiens 16020
-
3.2.1.106 membrane type-II transmembrane protein Sus scrofa 16020
-
3.2.1.106 microsome
-
 Homo sapiens
-
-
3.2.1.106 microsome
-
 Sus scrofa
-
-
3.2.1.106 additional information subcellular localization Homo sapiens
-
-
3.2.1.106 additional information subcellular localization Sus scrofa
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.2.1.106 additional information metal ions not required Homo sapiens
3.2.1.106 additional information metal ions not required Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.1.106 92000
-
 calculated from nucleotide sequence Homo sapiens
3.2.1.106 93000
-
 enzyme of 95000 Da degraded by endoglycosidase H, SDS-PAGE Homo sapiens
3.2.1.106 93000
-
 enzyme of 95000 Da degraded by endoglycosidase H, SDS-PAGE Sus scrofa
3.2.1.106 95000
-
 SDS-PAGE Homo sapiens
3.2.1.106 95000
-
 SDS-PAGE Sus scrofa
3.2.1.106 95000
-
 cDNA cloned, expressed in COS 1 cells, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.106 Glc3Man9GlcNAc2 + H2O Homo sapiens hydrolyses specifically terminal alpha1,2-linked glucose residue ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O Sus scrofa hydrolyses specifically terminal alpha1,2-linked glucose residue ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O Homo sapiens specific involvement in the N-linked oligosaccharide-processing pathway ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O Sus scrofa specific involvement in the N-linked oligosaccharide-processing pathway ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O Homo sapiens involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O Sus scrofa involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O Homo sapiens involved in processing of asparagine-linked oligosaccharides ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O Sus scrofa involved in processing of asparagine-linked oligosaccharides ?
-
 ?
3.2.1.106 additional information Homo sapiens involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins ?
-
 ?
3.2.1.106 additional information Sus scrofa involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins ?
-
 ?
3.2.1.106 additional information Homo sapiens involved in processing of asparagine-linked oligosaccharides ?
-
 ?
3.2.1.106 additional information Sus scrofa involved in processing of asparagine-linked oligosaccharides ?
-
 ?
3.2.1.106 additional information Homo sapiens involved in the formation of high mannose and complex glycoproteins ?
-
 ?
3.2.1.106 additional information Sus scrofa involved in the formation of high mannose and complex glycoproteins ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.106 Homo sapiens
-
-
-
3.2.1.106 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.2.1.106 glycoprotein single N-glycosylation site, N-glycosylation about 2-3 kDa Homo sapiens
3.2.1.106 glycoprotein single N-glycosylation site, N-glycosylation about 2-3 kDa Sus scrofa
3.2.1.106 glycoprotein with high-mannose oligosaccharides Homo sapiens
3.2.1.106 glycoprotein with high-mannose oligosaccharides Sus scrofa

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.1.106
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.106 hippocampus
-
 Homo sapiens
-
3.2.1.106 liver
-
 Homo sapiens
-
3.2.1.106 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.106 Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Homo sapiens D-glucose + Glc2Man9GlcNAc2
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Sus scrofa D-glucose + Glc2Man9GlcNAc2
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Homo sapiens ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Sus scrofa ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O specific involvement in the N-linked oligosaccharide-processing pathway Homo sapiens ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O specific involvement in the N-linked oligosaccharide-processing pathway Sus scrofa ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins Homo sapiens ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins Sus scrofa ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O involved in processing of asparagine-linked oligosaccharides Homo sapiens ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O involved in processing of asparagine-linked oligosaccharides Sus scrofa ?
-
 ?
3.2.1.106 additional information Glc1Man9GlcNAc2: not a substrate Homo sapiens ?
-
 ?
3.2.1.106 additional information Glc1Man9GlcNAc2: not a substrate Sus scrofa ?
-
 ?
3.2.1.106 additional information also acts, more slowly, on the corresponding glycolipids and glycopeptides Homo sapiens ?
-
 ?
3.2.1.106 additional information also acts, more slowly, on the corresponding glycolipids and glycopeptides Sus scrofa ?
-
 ?
3.2.1.106 additional information aryl-alpha-D-glucosides: not a substrate Homo sapiens ?
-
 ?
3.2.1.106 additional information aryl-alpha-D-glucosides: not a substrate Sus scrofa ?
-
 ?
3.2.1.106 additional information Glc2Man9GlcNAc2: not a substrate Homo sapiens ?
-
 ?
3.2.1.106 additional information Glc2Man9GlcNAc2: not a substrate Sus scrofa ?
-
 ?
3.2.1.106 additional information involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins Homo sapiens ?
-
 ?
3.2.1.106 additional information involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins Sus scrofa ?
-
 ?
3.2.1.106 additional information involved in processing of asparagine-linked oligosaccharides Homo sapiens ?
-
 ?
3.2.1.106 additional information involved in processing of asparagine-linked oligosaccharides Sus scrofa ?
-
 ?
3.2.1.106 additional information involved in the formation of high mannose and complex glycoproteins Homo sapiens ?
-
 ?
3.2.1.106 additional information involved in the formation of high mannose and complex glycoproteins Sus scrofa ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.106 6.4
-
-
 Sus scrofa