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Literature summary extracted from
- Comparison of retinyl ester hydrolase activities in bovine liver and retinal pigment epithelium (1996), J. Lipid Res., 37, 1947-1952.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.63 | additional information | the distinctive apparent inhibition constants for NEM-induced inhibition of 11-cis retinyl-palmitate hydrolase and the all-trans-retinyl-palmitate hydrolase activity suggest a fundamental difference in the amino acid composition at the active site of the enzyme(s) | Bos taurus | |
| 3.1.1.63 | NEM | inhibits all-trans retinyl-palmitate hydrolase and 11-cis-retinyl-palmitate hydrolase activity of the liver enzyme, inhibits all-trans-retinyl-palmitate hydrolase activity of the pigment epithelium, 1-cis-retinyl-palmitate hydrolase activity of the pigment epithelium is unaffected | Bos taurus |  |
| 3.1.1.63 | triolein | inhibits all-trans retinyl-palmitate hydrolase and 11-cis-retinyl-palmitate hydrolase activity of the liver enzyme, inhibits all-trans-retinyl-palmitate hydrolase activity of the pigment epithelium, 1-cis-retinyl-palmitate hydrolase activity of the pigment epithelium is unaffected | Bos taurus | |
| 3.1.1.64 | additional information | the distinctive apparent inhibition constants for NEM-induced inhibition of 11-cis retinyl-palmitate hydrolase and the all-trans-retinyl-palmitate hydrolase activity suggest a fundamental difference in the amino acid composition at the active site of the enzyme(s) | Bos taurus | |
| 3.1.1.64 | NEM | inhibits all-trans retinyl-palmitate hydrolase and 11-cis-retinyl-palmitate hydrolase activity of the liver enzyme, inhibits all-trans-retinyl-palmitate hydrolase activity of the pigment epithelium, 11-cis-retinyl-palmitate hydrolase activity of the pigment epithelium is unaffected | Bos taurus | |
| 3.1.1.64 | triolein | inhibits all-trans retinyl-palmitate hydrolase and 11-cis-retinyl-palmitate hydrolase activity of the liver enzyme, inhibits all-trans-retinyl-palmitate hydrolase activity of the pigment epithelium, 11-cis-retinyl-palmitate hydrolase activity of the pigment epithelium is unaffected | Bos taurus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.63 | Bos taurus | - |
- |
- |
| 3.1.1.64 | Bos taurus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.63 | liver | - |
Bos taurus | - |
| 3.1.1.63 | retinal pigment epithelium | - |
Bos taurus | - |
| 3.1.1.64 | liver | - |
Bos taurus | - |
| 3.1.1.64 | retinal pigment epithelium | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.63 | 11-cis-retinyl palmitate + H2O | - |
Bos taurus | 11-cis-retinol + palmitate | - |
? | |
| 3.1.1.64 | all-trans-retinyl palmitate + H2O | - |
Bos taurus | all-trans-retinol + palmitate | - |
? | |
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Release 2023.1 (January 2023)
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