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Literature summary extracted from

  • Busiello, V.; Di Girolamo, M.; Cini, C.; De Marco, C.
    beta-Selenaproline as competitive inhibitor of proline activation (1980), Biochim. Biophys. Acta, 606, 347-352.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.15 3-Selenaproline competitive Escherichia coli
6.1.1.15 3-Selenaproline competitive Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.1.1.15 0.4
-
 Pro ATP-diphosphate exchange Rattus norvegicus
6.1.1.15 0.8
-
 Pro 3-thiaproline, , ATP-diphosphate exchange Escherichia coli
6.1.1.15 1.4
-
 3-thiaproline ATP-diphosphate exchange Rattus norvegicus
6.1.1.15 6.25
-
 2-selenaproline ATP-diphosphate exchange Rattus norvegicus
6.1.1.15 12.5
-
 gamma-thiaproline ATP-diphosphate exchange Rattus norvegicus
6.1.1.15 66
-
 4-thiaproline ATP-diphosphate exchange Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.15 Escherichia coli
-
-
-
6.1.1.15 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.1.1.15 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.15 ATP + 2-selenaproline + tRNAPro
-
 Rattus norvegicus ?
-
 ?
6.1.1.15 ATP + 3-thiaproline + tRNAPro
-
 Rattus norvegicus ?
-
 ?
6.1.1.15 ATP + gamma-thiaproline + tRNAPro
-
 Rattus norvegicus ?
-
 ?
6.1.1.15 ATP + L-proline + tRNAPro
-
 Escherichia coli AMP + diphosphate + L-prolyl-tRNAPro
-
 ?
6.1.1.15 ATP + L-proline + tRNAPro
-
 Rattus norvegicus AMP + diphosphate + L-prolyl-tRNAPro
-
 ?
6.1.1.15 additional information ATP-diphosphate exchange Escherichia coli ?
-
 ?
6.1.1.15 additional information ATP-diphosphate exchange Rattus norvegicus ?
-
 ?
6.1.1.15 additional information 3-thiaproline, 4-thiaproline and 4-selenaproline can replace proline in the ATP-diphosphate exchange. 4-Thiaproline and 4-selenaproline show a much higher Km Escherichia coli ?
-
 ?
6.1.1.15 additional information 3-thiaproline, 4-thiaproline and 4-selenaproline can replace proline in the ATP-diphosphate exchange. 4-Thiaproline and 4-selenaproline show a much higher Km Rattus norvegicus ?
-
 ?