Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chu, S.Y.; Henderson, J.F.
    Purification and properties of phosphoribosyl-formylglycinamidine synthetase of Ehrlich ascites tumor cells (1972), Can. J. Biochem., 50, 484-489.
    View publication on PubMed

General Stability

EC Number General Stability Organism
6.3.5.3 a combination of Gln, MgCl2, and KCl protects against thermal inactivation Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.5.3 K+ required as activator, maximal activity at 10 mM KCl Mus musculus
6.3.5.3 NH4+ can replace K+ as activator Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.3 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.5.3
-
 Mus musculus

Reaction

EC Number Reaction Comment Organism Reaction ID
6.3.5.3 ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate ping-pong mechanism Mus musculus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.5.3 Ehrlich ascites carcinoma cell
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.5.3 additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.3 ATP + 5'-phosphoribosylformylglycinamide + L-Gln + H2O
-
 Mus musculus ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-Glu
-
 ?
6.3.5.3 ATP + 5'-phosphoribosylformylglycinamide + NH4+ + H2O
-
 Mus musculus ADP + phosphate + 5'-phosphoribosylformylglycinamidine
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
6.3.5.3 50
-
 5 min, up to 98% loss of activity. A combination of Gln, MgCl2, and KCl protects against thermal inactivation Mus musculus