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Literature summary extracted from

  • Schmidt, W.; Beerhues, L.
    Alternative pathways of xanthone biosynthesis in cell cultures of Hypericum androsaemum (1997), FEBS Lett., 420, 143-146.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.27 ATP + 4-hydroxybenzoate + CoA Hypericum androsaemum the enzyme is involved in xanthone biosynthesis AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
 ?
6.2.1.37 ATP + 3-hydroxybenzoate + CoA Hypericum androsaemum the enzyme is involved in xanthone biosynthesis AMP + diphosphate + 3-hydroxybenzoyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.151 Hypericum androsaemum
-
-
-
2.3.1.220 Hypericum androsaemum
-
-
-
6.2.1.27 Hypericum androsaemum
-
-
-
6.2.1.37 Hypericum androsaemum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.27 cell suspension culture
-
 Hypericum androsaemum
-
6.2.1.37 cell suspension culture
-
 Hypericum androsaemum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.151 2 malonyl-CoA + benzoyl-CoA
-
 Hypericum androsaemum 3 CoA + 2,4,6-trihydroxybenzophenone + 2 CO2
-
 ?
2.3.1.151 3 malonyl-CoA + 3-hydroxybenzoyl-CoA 49% of the activity with benzyol-CoA Hypericum androsaemum 4 CoA + 2,3',4,6-tetrahydroxybenzophenone + 3 CO2
-
 ?
2.3.1.151 Malonyl-CoA + 4-hydroxybenzoyl-CoA 5% of the activity with benzoyl-CoA Hypericum androsaemum ?
-
 ?
6.2.1.27 ATP + 4-hydroxybenzoate + CoA the enzyme is involved in xanthone biosynthesis Hypericum androsaemum AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
 ?
6.2.1.27 ATP + 4-hydroxybenzoate + CoA the bifunctional enzyme is also active with 3-hydroxybenzoate (cf. EC 6.2.1.37). Activity with 4-hydroxybenzoate is 69% compared to 3-hydroxybenzoate Hypericum androsaemum AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
 ?
6.2.1.37 ATP + 3-hydroxybenzoate + CoA the enzyme is involved in xanthone biosynthesis Hypericum androsaemum AMP + diphosphate + 3-hydroxybenzoyl-CoA
-
 ?
6.2.1.37 ATP + 3-hydroxybenzoate + CoA the bifunctional enzyme is also active with 4-hydroxybenzoate (cf. EC 6.2.1.27). Activity with 4-hydroxybenzoate is 69% compared to 3-hydroxybenzoate Hypericum androsaemum AMP + diphosphate + 3-hydroxybenzoyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.220 benzophenone synthase
-
 Hypericum androsaemum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.151 35
-
-
 Hypericum androsaemum
6.2.1.27 25
-
-
 Hypericum androsaemum
6.2.1.37 25
-
-
 Hypericum androsaemum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.151 7
-
-
 Hypericum androsaemum
6.2.1.27 8.5
-
-
 Hypericum androsaemum
6.2.1.37 8.5
-
-
 Hypericum androsaemum