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Literature summary extracted from

  • Galneder, E.; Rueffer, M.; Wanner, G.; Tabata, M.; Zenk, M.H.
    Alternative final steps in berberine biosynthesis in Coptis japonica cell cultures (1988), Plant Cell Rep., 7, 1-4.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.117 S-Adenosyl-L-methionine + (S)-scoulerine Berberis stolonifera
-
?
-
?
2.1.1.117 S-Adenosyl-L-methionine + (S)-scoulerine Coptis japonica the enzyme is responsible for a late step in the biosynthesis of berberine ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.68 Coptis japonica
-
-
-
2.1.1.117 Berberis stolonifera
-
-
-
2.1.1.117 Coptis japonica
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.19.68 (S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-canadine + [oxidized NADPH-hemoprotein reductase] + 2 H2O formation of a methylenedioxy bridge in ring A Coptis japonica

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.68 cell culture
-
Coptis japonica
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.117 S-Adenosyl-L-methionine + (S)-scoulerine
-
Berberis stolonifera S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine
-
?
2.1.1.117 S-Adenosyl-L-methionine + (S)-scoulerine
-
Coptis japonica S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine
-
?
2.1.1.117 S-Adenosyl-L-methionine + (S)-scoulerine
-
Berberis stolonifera ?
-
?
2.1.1.117 S-Adenosyl-L-methionine + (S)-scoulerine the enzyme is responsible for a late step in the biosynthesis of berberine Coptis japonica ?
-
?