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Literature summary extracted from

  • Buttlaire, D.H.; Balfe, C.A.; Wendland, M.F.; Himes, R.H.
    Carbamyl phosphate-dependent ATP synthesis catalyzed by formyltetrahydrofolate synthetase (1979), Biochim. Biophys. Acta, 567, 453-463.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.3 acetyl phosphate inhibits ATP synthesis reaction from carbamoyl phosphate and ADP, and synthesis of 10-formyltetrahydrofolate Clostridium cylindrosporum
6.3.4.3 Carbamoyl phosphate
-
 Clostridium cylindrosporum
6.3.4.3 formate inhibits ATP synthesis reaction from carbamoyl phosphate and ADP Clostridium cylindrosporum
6.3.4.3 phosphate inhibits ATP synthesis reaction from carbamoyl phosphate and ADP Clostridium cylindrosporum
6.3.4.3 Phosphonoacetate inhibits ATP synthesis reaction from carbamoyl phosphate and ADP, and synthesis of 10-formyltetrahydrofolate Clostridium cylindrosporum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.3 0.032
-
 ADP ATP synthesis from carbamoylphosphate Clostridium cylindrosporum
6.3.4.3 0.032 0.077 tetrahydrofolate ATP synthesis Clostridium cylindrosporum
6.3.4.3 0.13
-
 ADP formyltetrahydrofolate synthesis Clostridium cylindrosporum
6.3.4.3 0.27
-
 tetrahydrofolate formyltretrahydrofolate synthesis Clostridium cylindrosporum
6.3.4.3 11.9
-
 Carbamoyl phosphate
-
 Clostridium cylindrosporum

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.3 Clostridium cylindrosporum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.3 ATP + formate + tetrahydrofolate r Clostridium cylindrosporum ADP + phosphate + 10-formyltetrahydrofolate
-
 ?
6.3.4.3 Carbamoyl phosphate + ADP
-
 Clostridium cylindrosporum ? + ATP
-
 ?