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Literature summary extracted from

  • Schegg, K.M.; Welch jr., W.
    The effect of nordihydroguaiaretic acid and related lignans on formyltetrahydrofolate synthetase and carboxylesterase (1984), Biochim. Biophys. Acta, 788, 167-180.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.3 Heminordihydroguaiaretic acid
-
 Bos taurus
6.3.4.3 Heminordihydroguaiaretic acid
-
 Cavia porcellus
6.3.4.3 Heminordihydroguaiaretic acid
-
 Homo sapiens
6.3.4.3 Heminordihydroguaiaretic acid
-
 Mus musculus
6.3.4.3 Heminordihydroguaiaretic acid
-
 Rattus norvegicus
6.3.4.3 nordihydroguaiaretic acid
-
 Bos taurus
6.3.4.3 nordihydroguaiaretic acid
-
 Cavia porcellus
6.3.4.3 nordihydroguaiaretic acid
-
 Homo sapiens
6.3.4.3 nordihydroguaiaretic acid
-
 Mus musculus
6.3.4.3 nordihydroguaiaretic acid
-
 Rattus norvegicus
6.3.4.3 Norisoguaiacin
-
 Bos taurus
6.3.4.3 Norisoguaiacin
-
 Cavia porcellus
6.3.4.3 Norisoguaiacin
-
 Homo sapiens
6.3.4.3 Norisoguaiacin
-
 Mus musculus
6.3.4.3 Norisoguaiacin
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.3 Bos taurus
-
-
-
6.3.4.3 Cavia porcellus
-
-
-
6.3.4.3 Homo sapiens
-
 trifunctional enzyme with 10-formyltetrahydrofolate synthetase, EC 6.3.4.3, 5,10-methenyltetrahydrofolate cyclohydrolase, EC 3.5.4.9, and 5,10-methylenetetrahydrofolate dehydrogenase activity, EC 1.5.1.5
-
6.3.4.3 Mus musculus
-
-
-
6.3.4.3 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.3 brain
-
 Rattus norvegicus
-
6.3.4.3 CCRF S-180 II cell
-
 Mus musculus
-
6.3.4.3 HeLa cell
-
 Homo sapiens
-
6.3.4.3 kidney
-
 Cavia porcellus
-
6.3.4.3 kidney
-
 Mus musculus
-
6.3.4.3 kidney
-
 Rattus norvegicus
-
6.3.4.3 kidney
-
 Bos taurus
-
6.3.4.3 liver
-
 Mus musculus
-
6.3.4.3 liver
-
 Rattus norvegicus
-
6.3.4.3 skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.3 ATP + formate + tetrahydrofolate
-
 Cavia porcellus ADP + phosphate + 10-formyltetrahydrofolate
-
 ?
6.3.4.3 ATP + formate + tetrahydrofolate
-
 Mus musculus ADP + phosphate + 10-formyltetrahydrofolate
-
 ?
6.3.4.3 ATP + formate + tetrahydrofolate
-
 Homo sapiens ADP + phosphate + 10-formyltetrahydrofolate
-
 ?
6.3.4.3 ATP + formate + tetrahydrofolate
-
 Rattus norvegicus ADP + phosphate + 10-formyltetrahydrofolate
-
 ?
6.3.4.3 ATP + formate + tetrahydrofolate
-
 Bos taurus ADP + phosphate + 10-formyltetrahydrofolate
-
 ?