Literature summary extracted from

Britton, H.G.; Rubio, V.; Grisolia, S.
Synthesis of carbamoyl phosphate by carbamoyl phosphate synthetase I in the absence of acetylglutamate. Activation of the enzyme by cryoprotectants (1981), Biochem. Biophys. Res. Commun., 99, 1131-1137.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
6.3.4.16	acetylglutamate	no activity in absence of	Rattus norvegicus
6.3.4.16	dimethyl sulfoxide	activates in absence of the activator acetylglutamate	Rattus norvegicus
6.3.4.16	ethylene glycol	activates in absence of the activator acetylglutamate	Rattus norvegicus
6.3.4.16	glycerol	activates in absence of the activator acetylglutamate	Rattus norvegicus
6.3.4.16	sucrose	activates in absence of the activator acetylglutamate	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.3.4.16	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
6.3.4.16	liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.3.4.16	ATP + NH4+ + CO2 + H2O	-	Rattus norvegicus	ADP + phosphate + carbamoylphosphate	-	?

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Release 2023.1 (January 2023)