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Literature summary extracted from

  • Alonso, E.; Rubio, V.
    Inactivation of mitochondrial carbamoyl phosphate synthetase induced by ascorbate, oxygen, and Fe3+ in the presence of acetylglutamate: protection by ATP and HCO3- and lack of inactivation of ornithine transcarbamylase (1987), Arch. Biochem. Biophys., 258, 342-350.
    View publication on PubMed

General Stability

EC Number General Stability Organism
6.3.4.16 inactivated by the Fe3+-oxygen-ascorbate model system for mixed-function oxidation. The susceptibility is markedly increased by acetylglutamate, when ATP is absent. ATP, and even more a mixture of ATP and bicarbonate protect from inactivation Rattus norvegicus
6.3.4.16 trypsin, chymotrypsin, and papain also hydrolyze the oxidized enzyme considerybly faster than the native enzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.16 2 ATP + NH3 + CO2 + H2O Rattus norvegicus enzyme of urea cycle ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.16 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.16 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.16 2 ATP + NH3 + CO2 + H2O enzyme of urea cycle Rattus norvegicus ?
-
?
6.3.4.16 ATP + NH4+ + CO2 + H2O
-
Rattus norvegicus ADP + phosphate + carbamoylphosphate
-
?