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Literature summary extracted from

  • Chiba, Y.; Suzuki, Y.; Aoki, Y.; Ishida, Y.; Narisawa, K.
    Purification and properties of bovine liver holocarboxylase synthetase (1994), Arch. Biochem. Biophys., 313, 8-14.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.10 0.000013
-
 biotin
-
 Bos taurus
6.3.4.10 0.02
-
 ATP
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.4.10 cytosol
-
 Bos taurus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.4.10 60000
-
 gel filtration Bos taurus
6.3.4.10 64000
-
 1 * 64000, SDS-PAGE Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.10 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.4.10
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.4.10 0.514
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.10 ATP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] biotinylates apopropionyl-CoA carboxylase from patients with holocarboxylase synthetase deficiency Bos taurus AMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?
6.3.4.10 CTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] 117% of the activity relative to ATP Bos taurus CMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?
6.3.4.10 GTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] 46% of the activity relative to ATP Bos taurus GMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?
6.3.4.10 ITP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] 47% of the activity relative to ATP Bos taurus IMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.4.10 monomer 1 * 64000, SDS-PAGE Bos taurus